Literature DB >> 12891709

Forkhead transcription factor FoxO1 transduces insulin-like growth factor's signal to p27Kip1 in primary skeletal muscle satellite cells.

Shuichi Machida1, Espen E Spangenburg, Frank W Booth.   

Abstract

The insulin-like growth factor I (IGF-I) stimulates muscle satellite cell proliferation. Chakravarthy et al., (2000, J Biol Chem 275:35942-35952.) previously found that IGF-I-stimulated proliferation of primary satellite cells was associated with the activation of phosphatidylinositol 3'-kinase (PI3K)/Akt and the downregulation of a cell-cycle inhibitor p27Kip1. To understand mechanisms by which IGF-I signals the downregulation of p27Kip1 in rat skeletal satellite cells, the role of Forkhead transcription factor FoxO1 in transcriptional activity of p27Kip1 was examined. When primary rat satellite cells were transfected with a p27Kip1 promoter-reporter gene construct, IGF-I (100 ng/ml) inhibited specific p27Kip1 promoter activity. Addition of LY294002, an inhibitor of PI3K, reversed the IGF-I-mediated downregulation of p27Kip1 promoter activity. Co-transfection of wild type (WT) FoxO1 into satellite cells increased p27Kip1 promoter activity in the absence of IGF-I supplementation. Addition of IGF-I reversed the induction of p27Kip1 promoter activity by WT FoxO1. When a mutated FoxO1 (without Thr24, Ser256, and Ser316 Akt phosphorylation sites) was used, IGF-I was no longer able to reverse the FoxO1 induced stimulation of p27Kip1 promoter activity that had been seen when WT FoxO1 was present. When the satellite cells were treated with IGF-I, phosphorylation of Akt-Ser473 and FoxO1-Ser256 was increased. In addition, when the cells were pre-incubated with LY294002 before IGF-I stimulation, the phosphorylation of Akt-Ser473 and FoxO1-Ser256 was inhibited, implying that phosphorylation of Akt and FoxO1 was downstream of IGF-I-induced PI3K signaling. However, IGF-I did not induce phosphorylation of FoxO1 on residues Thr24 and Ser316. These results suggested that IGF-I induced the phosphorylation of Ser256 and inactivated FoxO1 thereby downregulating the activation of the p27Kip1 promoter. Thus, inactivation of FoxO1 by IGF-I plays a critical role in rat skeletal satellite cell proliferation through regulation of p27Kip1 expression. Copyright 2003 Wiley-Liss, Inc.

Entities:  

Keywords:  Non-programmatic

Mesh:

Substances:

Year:  2003        PMID: 12891709     DOI: 10.1002/jcp.10339

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN: 0021-9541            Impact factor:   6.384


  37 in total

1.  Primary rat muscle progenitor cells have decreased proliferation and myotube formation during passages.

Authors:  S Machida; E E Spangenburg; F W Booth
Journal:  Cell Prolif       Date:  2004-08       Impact factor: 6.831

Review 2.  Current evidence that exercise can increase the number of adult stem cells.

Authors:  F Macaluso; K H Myburgh
Journal:  J Muscle Res Cell Motil       Date:  2012-06-07       Impact factor: 2.698

3.  Isolation of putative FOXO1 genomic elements using an improved in vitro technique to isolate genomic regulatory sequences.

Authors:  Alpa Sidhu; Patrick J Miller; Andrew D Hollenbach
Journal:  Gene       Date:  2010-03-23       Impact factor: 3.688

Review 4.  New fundamental resistance exercise determinants of molecular and cellular muscle adaptations.

Authors:  Marco Toigo; Urs Boutellier
Journal:  Eur J Appl Physiol       Date:  2006-08       Impact factor: 3.078

5.  Impairment of IGF-I expression and anabolic signaling following ischemia/reperfusion in skeletal muscle of old mice.

Authors:  David W Hammers; Ronald W Matheny; Christian Sell; Martin L Adamo; Thomas J Walters; J Scot Estep; Roger P Farrar
Journal:  Exp Gerontol       Date:  2010-11-18       Impact factor: 4.032

Review 6.  FoxO transcription factors: their roles in the maintenance of skeletal muscle homeostasis.

Authors:  Anthony M J Sanchez; Robin B Candau; Henri Bernardi
Journal:  Cell Mol Life Sci       Date:  2014-05       Impact factor: 9.261

7.  Insulin-like growth factor 1 regulation of proliferation and differentiation of Xenopus laevis myogenic cells in vitro.

Authors:  Sairi Miyata; Tomotaka Yada; Natsuko Ishikawa; Kazi Taheruzzaman; Ryohei Hara; Takashi Matsuzaki; Akio Nishikawa
Journal:  In Vitro Cell Dev Biol Anim       Date:  2016-10-03       Impact factor: 2.416

8.  CC family chemokines directly regulate myoblast responses to skeletal muscle injury.

Authors:  Linda Yahiaoui; Dusanka Gvozdic; Gawiyou Danialou; Matthias Mack; Basil J Petrof
Journal:  J Physiol       Date:  2008-06-19       Impact factor: 5.182

Review 9.  Leptin Signaling in the Control of Metabolism and Appetite: Lessons from Animal Models.

Authors:  Alberto A Barrios-Correa; José A Estrada; Irazú Contreras
Journal:  J Mol Neurosci       Date:  2018-10-03       Impact factor: 3.444

10.  KRIT1 regulates the homeostasis of intracellular reactive oxygen species.

Authors:  Luca Goitre; Fiorella Balzac; Simona Degani; Paolo Degan; Saverio Marchi; Paolo Pinton; Saverio Francesco Retta
Journal:  PLoS One       Date:  2010-07-26       Impact factor: 3.240

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.