Heon-Jeong Lee1, Yong-Ku Kim. 1. Department of Psychiatry, Korea University, College of Medicine, Ansan City, Korea.
Abstract
OBJECTIVE: To determine whether a correlation exists between lower serum lipid concentrations and increased suicide risk. METHOD: Serum lipid profiles were pair-matched for 60 patients who had recently experienced failed attempts at suicide and equal numbers of non-suicidal psychiatric patients, and normal controls. Suicide attempt severity was scored using Weisman and Worden's risk-rescue rating scale. RESULTS: (a). Total serum cholesterol and low density lipoprotein levels were found to be lower in the parasuicidal population at statistically significant levels (P < 0.01 and <0.05, respectively); (b). triglyceride concentrations were lower in suicide attempters with major depression compared with non-suicidal depressed patients; and (c). risk-rescue rating scores were negatively correlated with total serum cholesterol levels (r = -0.347, P = 0.007). CONCLUSION: Low lipid metabolism may be a potential biological marker in the assessment of suicide risk. Further investigations are necessary to elucidate the biological mechanisms of these findings.
OBJECTIVE: To determine whether a correlation exists between lower serum lipid concentrations and increased suicide risk. METHOD: Serum lipid profiles were pair-matched for 60 patients who had recently experienced failed attempts at suicide and equal numbers of non-suicidal psychiatricpatients, and normal controls. Suicide attempt severity was scored using Weisman and Worden's risk-rescue rating scale. RESULTS: (a). Total serum cholesterol and low density lipoprotein levels were found to be lower in the parasuicidal population at statistically significant levels (P < 0.01 and <0.05, respectively); (b). triglyceride concentrations were lower in suicide attempters with major depression compared with non-suicidal depressedpatients; and (c). risk-rescue rating scores were negatively correlated with total serum cholesterol levels (r = -0.347, P = 0.007). CONCLUSION: Low lipid metabolism may be a potential biological marker in the assessment of suicide risk. Further investigations are necessary to elucidate the biological mechanisms of these findings.
Authors: Richard A Labrie; Debi A Laplante; Allyson J Peller; Donald E Christensen; Kristina L Greenwood; John H Straus; Michael S Garmon; Cheryl Browne; Howard J Shaffer Journal: Int J Integr Care Date: 2007-05-16 Impact factor: 5.120
Authors: Marcela Segoviano-Mendoza; Manuel Cárdenas-de la Cruz; José Salas-Pacheco; Fernando Vázquez-Alaniz; Osmel La Llave-León; Francisco Castellanos-Juárez; Jazmín Méndez-Hernández; Marcelo Barraza-Salas; Ernesto Miranda-Morales; Oscar Arias-Carrión; Edna Méndez-Hernández Journal: BMC Psychiatry Date: 2018-01-15 Impact factor: 3.630