"Formal" ruthenium-catalyzed [4+2+2] cycloaddition of 1,6-diynes to 1,3-dienes: formation of cyclooctatrienes vs vinylcyclohexadienes.

[reaction: see text] A new "formal" Ru-catalyzed [4+2+2] cycloaddition of 1,6-diynes to 1,3-dienes giving conjugated 1,3,5-cyclooctatrienes and vinylcyclohexadienes is described. This formal cycloaddition is really a tandem process, the Ru(II)-catalyzed formation of (Z)-tetraenes or vinyl-(Z)-trienes followed by a pure thermal conrotatory 8 pi- or disrotatory 6 pi-electrocyclization. The proposed mechanism allows the differences in product ratio to be explained in terms of steric and stereochemical considerations.