OBJECTIVE: To test the sensitivity of whole-brain T1 relaxometry to the evolution of pathological changes in multiple sclerosis (MS). BACKGROUND: T1-weighted hypointense lesion load in the brains of patients with MS is associated with axonal loss. Other work has shown that T1 measurements may provide information complementary to existing imaging techniques, such as magnetization transfer imaging. METHODS: The authors studied 14 MS patients twice over a median time interval of 19.5 months (range, 14-22 months). Structural images and whole-brain T1 maps using a novel rapid-scanning technique (3 min/study) were performed at 3 T. Analysis focused on defining changes separately in the lesional and normal-appearing white matter (NAWM) and in the cortical gray matter. RESULTS: At baseline, there was an inverse relationship between disease duration and the NAWM T1 histogram peak height (r = -0.75, P = .03). The total white matter T1 histogram peak height decreased over time (P < .001). This could be accounted for by changes in the NAWM (P < .03). There also was a decrease (6%) in the mean (11 of 14 patients, P = .004) and in the median (7%) (13 of 14 patients, P < .001) neocortical gray matter T1 over the follow-up period. CONCLUSIONS: Brain T1 maps can be generated quickly and are sensitive to pathological changes over time. T1 values in both the gray and the white matter at the baseline visit were related to disease duration, suggesting that the T1 changes are clinically relevant. Although the absolute values will be different, it is likely that similar changes will be able to be detected at 1.5 T. The role of T1 measurement as a magnetic resonance imaging outcome measure in clinical trials now should be explored.
OBJECTIVE: To test the sensitivity of whole-brain T1 relaxometry to the evolution of pathological changes in multiple sclerosis (MS). BACKGROUND: T1-weighted hypointense lesion load in the brains of patients with MS is associated with axonal loss. Other work has shown that T1 measurements may provide information complementary to existing imaging techniques, such as magnetization transfer imaging. METHODS: The authors studied 14 MS patients twice over a median time interval of 19.5 months (range, 14-22 months). Structural images and whole-brain T1 maps using a novel rapid-scanning technique (3 min/study) were performed at 3 T. Analysis focused on defining changes separately in the lesional and normal-appearing white matter (NAWM) and in the cortical gray matter. RESULTS: At baseline, there was an inverse relationship between disease duration and the NAWM T1 histogram peak height (r = -0.75, P = .03). The total white matter T1 histogram peak height decreased over time (P < .001). This could be accounted for by changes in the NAWM (P < .03). There also was a decrease (6%) in the mean (11 of 14 patients, P = .004) and in the median (7%) (13 of 14 patients, P < .001) neocortical gray matter T1 over the follow-up period. CONCLUSIONS: Brain T1 maps can be generated quickly and are sensitive to pathological changes over time. T1 values in both the gray and the white matter at the baseline visit were related to disease duration, suggesting that the T1 changes are clinically relevant. Although the absolute values will be different, it is likely that similar changes will be able to be detected at 1.5 T. The role of T1 measurement as a magnetic resonance imaging outcome measure in clinical trials now should be explored.
Authors: Alice L W Liang; Irene M Vavasour; Burkhard Mädler; Anthony L Traboulsee; Donna J Lang; David K B Li; Alex L MacKay; Cornelia Laule Journal: J Neurol Date: 2011-11-26 Impact factor: 4.849
Authors: C Thaler; T D Faizy; J Sedlacik; B Holst; K Stürner; C Heesen; J-P Stellmann; J Fiehler; S Siemonsen Journal: AJNR Am J Neuroradiol Date: 2016-11-10 Impact factor: 3.825
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Authors: Benjamin S Aribisala; Natalie A Royle; Susana Muñoz Maniega; Maria C Valdés Hernández; Catherine Murray; Lars Penke; Alan Gow; John M Starr; Mark E Bastin; Ian J Deary; Joanna M Wardlaw Journal: Cortex Date: 2013-12-31 Impact factor: 4.027
Authors: Devasuda Anblagan; Maria C Valdés Hernández; Stuart J Ritchie; Benjamin S Aribisala; Natalie A Royle; Iona F Hamilton; Simon R Cox; Alan J Gow; Alison Pattie; Janie Corley; John M Starr; Susana Muñoz Maniega; Mark E Bastin; Ian J Deary; Joanna M Wardlaw Journal: Brain Behav Date: 2018-01-04 Impact factor: 2.708