[Correlation between prognosis and the expression of eukaryotic translation initiation factor 4E in surgical margin specimen of laryngeal squamous cell carcinoma].

OBJECTIVE: To reveal the correlation between prognosis and the expression of eIF4E in the pathological negative surgical margin patients of laryngeal squamous cell carcinoma (SCC).
METHODS: Immunohistochemistry was used to detect the expression of eIF4E protein in the pathological negative margin specimen and primary site of cancer of 67 patients, and 5 year survival rate data of those patients was analyzed retrospectively.
RESULTS: The positive expression rate of eIF4E protein in surgical margin and primary site of cancer was 32.8% (22/67) and 100% (67/67) respectively. As for the control group, in which the eIF4E protein expression was not be found. The local recurrence rate was 63.6% for patients with eIF4E positive margin and 28.9% for patients with eIF4E negative margin (P = 0.006). The 5-year survival rate of patients with eIF4E positive margin was lower than those with negative margin (43.31% vs 77.52%, P = 0.0006).
CONCLUSION: The prognosis of patients with eIF4E protein positive expression in the pathological negative surgical margin may be worse than those of the negative.