Literature DB >> 12888984

Anabaptist genealogy database.

Richa Agarwala1, Leslie G Biesecker, Alejandro A Schäffer.   

Abstract

In late 1996 we set out to build a computer-searchable genealogy of the Old Order Amish of Lancaster County, Pennsylvania, for use by geneticists. The goals of the project included: 1) using the genealogy to expedite the mapping of genes mutated in three rare recessive disorders under study at the National Institutes of Health (NIH); 2) building a freely available software package, PedHunter, to answer genetically relevant queries on our database and other similar databases; and 3) providing genealogy assistance to researchers outside NIH. All of these scientific goals had to be accomplished while maintaining the confidentiality of the persons in the database and the confidentiality of preliminary research results. We expanded the project to include complementary data sources that contained many individuals who were Anabaptist, but not Amish, and many individuals who never lived in Lancaster County. For this reason, the project was renamed Anabaptist Genealogy Database (AGDB). All of the initial goals of the project have been accomplished, and we recently marked the 5-year anniversary of answering the first of over 100 queries by researchers outside NIH. Thus, it is an opportune time to review the construction of AGDB, summarize its usage to date, and speculate on future projects it might stimulate and facilitate. Published 2003 Wiley-Liss, Inc.

Entities:  

Mesh:

Year:  2003        PMID: 12888984     DOI: 10.1002/ajmg.c.20004

Source DB:  PubMed          Journal:  Am J Med Genet C Semin Med Genet        ISSN: 1552-4868            Impact factor:   3.908


  36 in total

1.  Linkage and association of successful aging to the 6q25 region in large Amish kindreds.

Authors:  Digna R Velez Edwards; John R Gilbert; James E Hicks; Jamie L Myers; Lan Jiang; Anna C Cummings; Shengru Guo; Paul J Gallins; Ioanna Konidari; Laura Caywood; Lori Reinhart-Mercer; Denise Fuzzell; Claire Knebusch; Renee Laux; Charles E Jackson; Margaret A Pericak-Vance; Jonathan L Haines; William K Scott
Journal:  Age (Dordr)       Date:  2012-07-07

2.  Mitochondrial haplogroup X is associated with successful aging in the Amish.

Authors:  Monique D Courtenay; John R Gilbert; Lan Jiang; Anna C Cummings; Paul J Gallins; Laura Caywood; Lori Reinhart-Mercer; Denise Fuzzell; Claire Knebusch; Renee Laux; Jacob L McCauley; Charles E Jackson; Margaret A Pericak-Vance; Jonathan L Haines; William K Scott
Journal:  Hum Genet       Date:  2011-07-13       Impact factor: 4.132

3.  Investigations of the Y chromosome, male founder structure and YSTR mutation rates in the Old Order Amish.

Authors:  Toni I Pollin; Daniel J McBride; Richa Agarwala; Alejandro A Schäffer; Alan R Shuldiner; Braxton D Mitchell; Jeffrey R O'Connell
Journal:  Hum Hered       Date:  2007-09-26       Impact factor: 0.444

4.  Electronically ascertained extended pedigrees in breast cancer genetic counseling.

Authors:  V Stefansdottir; H Skirton; O Th Johannsson; H Olafsdottir; G H Olafsdottir; L Tryggvadottir; J J Jonsson
Journal:  Fam Cancer       Date:  2019-04       Impact factor: 2.375

5.  Optimized selection of unrelated subjects for whole-genome sequencing studies of rare high-penetrance alleles.

Authors:  Todd L Edwards; Chun Li
Journal:  Genet Epidemiol       Date:  2012-05-23       Impact factor: 2.135

6.  A genome-wide linkage screen in the Amish with Parkinson disease points to chromosome 6.

Authors:  Anna C Cummings; Stephen L Lee; Jacob L McCauley; Lan Jiang; Amy Crunk; Lynne L McFarland; Paul J Gallins; Denise Fuzzell; Clare Knebusch; Charles E Jackson; William K Scott; Margaret A Pericak-Vance; Jonathan L Haines
Journal:  Ann Hum Genet       Date:  2011-05       Impact factor: 1.670

7.  Successful aging shows linkage to chromosomes 6, 7, and 14 in the Amish.

Authors:  Digna R Velez Edwards; John R Gilbert; Lan Jiang; Paul J Gallins; Laura Caywood; Marilyn Creason; Denise Fuzzell; Clare Knebusch; Charles E Jackson; Margaret A Pericak-Vance; Jonathan L Haines; William K Scott
Journal:  Ann Hum Genet       Date:  2011-07       Impact factor: 1.670

8.  The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin.

Authors:  Laura M Bozzi; Braxton D Mitchell; Joshua P Lewis; Kathy A Ryan; William R Herzog; Jeffrey R O'Connell; Richard B Horenstein; Alan R Shuldiner; Laura M Yerges-Armstrong
Journal:  Curr Vasc Pharmacol       Date:  2016       Impact factor: 2.719

9.  PedHunter 2.0 and its usage to characterize the founder structure of the Old Order Amish of Lancaster County.

Authors:  Woei-Jyh Lee; Toni I Pollin; Jeffrey R O'Connell; Richa Agarwala; Alejandro A Schäffer
Journal:  BMC Med Genet       Date:  2010-05-02       Impact factor: 2.103

10.  Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.

Authors:  Anna C Cummings; Lan Jiang; Digna R Velez Edwards; Jacob L McCauley; Renee Laux; Lynne L McFarland; Denise Fuzzell; Clare Knebusch; Laura Caywood; Lori Reinhart-Mercer; Laura Nations; John R Gilbert; Ioanna Konidari; Michael Tramontana; Michael L Cuccaro; William K Scott; Margaret A Pericak-Vance; Jonathan L Haines
Journal:  Ann Hum Genet       Date:  2012-09       Impact factor: 1.670

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.