Literature DB >> 12888006

Cell polarity: the ups and downs of the Par6/aPKC complex.

Domingos Henrique1, François Schweisguth.   

Abstract

A signaling complex in which atypical protein kinase C associates with a regulatory protein, Par6, plays an essential role in establishing cell polarity. Recent studies in organisms ranging from worms to mammals have highlighted some of the conserved mechanisms by which the assembly, localization and activity of this complex are regulated. Recent work is also beginning to unravel how this complex acts in concert with additional molecular complexes to establish and maintain polarity.

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Year:  2003        PMID： 12888006     DOI： 10.1016/s0959-437x(03)00077-7

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  40 in total

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Authors:  Zezhou Wang; Shawn S-C Li
Journal:  Cell Adh Migr       Date:  2010-04-16       Impact factor: 3.405

2.  aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.

Authors:  Christian A Smith; Kimberly M Lau; Zohra Rahmani; Sascha E Dho; Greg Brothers; Ye Min She; Donna M Berry; Eric Bonneil; Pierre Thibault; François Schweisguth; Roland Le Borgne; C Jane McGlade
Journal:  EMBO J       Date:  2007-01-04       Impact factor: 11.598

3.  Characterization of mammalian Par 6 as a dual-location protein.

Authors:  Erin G Cline; W James Nelson
Journal:  Mol Cell Biol       Date:  2007-04-09       Impact factor: 4.272

4.  Transcriptional modulation of genes encoding structural characteristics of differentiating enterocytes during development of a polarized epithelium in vitro.

Authors:  Jennifer M Halbleib; Annika M Sääf; Patrick O Brown; W James Nelson
Journal:  Mol Biol Cell       Date:  2007-08-15       Impact factor: 4.138

5.  Instructive role of aPKCzeta subcellular localization in the assembly of adherens junctions in neural progenitors.

Authors:  Sourav Ghosh; Till Marquardt; Joshua P Thaler; Nigel Carter; Shane E Andrews; Samuel L Pfaff; Tony Hunter
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-27       Impact factor: 11.205

6.  Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins.

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Journal:  Mol Cell Biol       Date:  2009-03-02       Impact factor: 4.272

7.  Loss of podocyte aPKClambda/iota causes polarity defects and nephrotic syndrome.

Authors:  Tobias B Huber; Björn Hartleben; Kirstin Winkelmann; Lisa Schneider; Jan U Becker; Michael Leitges; Gerd Walz; Hermann Haller; Mario Schiffer
Journal:  J Am Soc Nephrol       Date:  2009-03-11       Impact factor: 10.121

8.  Competing molecular interactions of aPKC isoforms regulate neuronal polarity.

Authors:  Sara S Parker; Edward K Mandell; Sophie M Hapak; Irina Y Maskaykina; Yael Kusne; Ji-Young Kim; Jamie K Moy; Paul A St John; Jean M Wilson; Katalin M Gothard; Theodore J Price; Sourav Ghosh
Journal:  Proc Natl Acad Sci U S A       Date:  2013-08-12       Impact factor: 11.205

9.  Transgenic expression of constitutively active RAC1 disrupts mouse rod morphogenesis.

Authors:  Hongman Song; Ronald A Bush; Camasamudram Vijayasarathy; Robert N Fariss; Sten Kjellstrom; Paul A Sieving
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-04-25       Impact factor: 4.799

10.  Atypical protein kinase C phosphorylates Par6 and facilitates transforming growth factor β-induced epithelial-to-mesenchymal transition.

Authors:  Adrian Gunaratne; Boun L Thai; Gianni M Di Guglielmo
Journal:  Mol Cell Biol       Date:  2012-12-17       Impact factor: 4.272
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