Literature DB >> 12884914

Role of MAP kinase in tumor progression and invasion.

Kaladhar B Reddy1, Sanaa M Nabha, Natasha Atanaskova.   

Abstract

Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway is a frequent event in tumorigenesis. MAPKs have been implicated in cell migration, proteinase-induction, regulation of apoptosis, and angiogenesis, events that are essential for successful completion of metastasis. In this review, we discuss the potential role that MAPKs play in metastasis by regulating cell migration, proteinase-induction and apoptosis.

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Year:  2003        PMID： 12884914     DOI： 10.1023/a:1023781114568

Source DB:  PubMed          Journal:  Cancer Metastasis Rev        ISSN： 0167-7659            Impact factor:   9.264


  175 in total

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