L Schiffmann1, B Mann, H Hotz, H J Buhr. 1. Chirurgische Klinik I, Universitätsklinikum Benjamin Franklin, Berlin. Schiffmann@medizin.fu-berlin.de
Abstract
BACKGROUND: Standard for treatment of pHPT has been the exploration of the neck and extirpation of the macroscopic identified adenoma for a long time. Since the Quick-PTH-Assay is available as intraoperative control of success, it is possible to extirpate a preoperativeley localized adenoma without identifying the normal parathyroid glands. Since the accuracy of the preoperative localization is essential for a minimally invasive or endoscopic procedure, we analyzed retrospectively the accuracy of ultrasound and mibiscan of our patients, operated due to pHPT in our facility. METHODS: Between 1995 and 2002 119 patients were operated due to HPT in our facility. Sensitivity, specificity, positive- and negative-predictive value for diagnosis and correct localisation of a singular adenoma by ultrasound and/or mibiscan were determined. RESULTS: We found a singular adenoma in 94 patients, a carcinoma in 1 patient, 6-times a double-adenoma and in 18 cases a hyperplasia of all parathyroid glands. Sensitivity, specificity, positive- and negative-predictive value for diagnosis and correct localisation of a singular adenoma were 52 %, 41 %, 60 % and 27 % rsp., when the results of mibiscan and ultrasound were used. DISCUSSION: Related to the preoperative imaging, a single gland exploration and extirpation would have been possible in 70 % of our patients with pHPT. However, in 40 % of these patients the 100 % reliable Quick-PTH-Assay would have shown, that the adenoma has not been removed successfully in the first attempt.
BACKGROUND: Standard for treatment of pHPT has been the exploration of the neck and extirpation of the macroscopic identified adenoma for a long time. Since the Quick-PTH-Assay is available as intraoperative control of success, it is possible to extirpate a preoperativeley localized adenoma without identifying the normal parathyroid glands. Since the accuracy of the preoperative localization is essential for a minimally invasive or endoscopic procedure, we analyzed retrospectively the accuracy of ultrasound and mibiscan of our patients, operated due to pHPT in our facility. METHODS: Between 1995 and 2002 119 patients were operated due to HPT in our facility. Sensitivity, specificity, positive- and negative-predictive value for diagnosis and correct localisation of a singular adenoma by ultrasound and/or mibiscan were determined. RESULTS: We found a singular adenoma in 94 patients, a carcinoma in 1 patient, 6-times a double-adenoma and in 18 cases a hyperplasia of all parathyroid glands. Sensitivity, specificity, positive- and negative-predictive value for diagnosis and correct localisation of a singular adenoma were 52 %, 41 %, 60 % and 27 % rsp., when the results of mibiscan and ultrasound were used. DISCUSSION: Related to the preoperative imaging, a single gland exploration and extirpation would have been possible in 70 % of our patients with pHPT. However, in 40 % of these patients the 100 % reliable Quick-PTH-Assay would have shown, that the adenoma has not been removed successfully in the first attempt.