Literature DB >> 12883704

Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and non-small cell lung cancer.

Krzysztof Siemianowicz1, Jan Gminski, Wojciech Garczorz, Natalia Slabiak, Malgorzata Goss, Marek Machalski, Helena Magiera-Molendowska.   

Abstract

Two mutations of methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) may lead to a decreased activity of the enzyme. These mutations may change a risk of some cancers. We evaluated these two polymorphisms of MTHFR in patients with small cell lung cancer (SCLC) and non-small cell lung cancer (NCSCL). All lung cancer patients had statistically significantly higher percentage of MTHFR 677TT genotype in comparison with non-cancer controls. There were no statistically significant differences in the distribution of MTHFR 1298 genotypes. Neither of the polymorphisms presented any statistically significant differences between SCLC and NSCLC.

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Year:  2003        PMID： 12883704

Source DB:  PubMed          Journal:  Oncol Rep        ISSN： 1021-335X            Impact factor:   3.906


  15 in total

1.  The association between methylene-tetrahydrofolate reductase gene polymorphism and lung cancer risk.

Authors:  Sulhattin Arslan; Sule Karadayi; Malik Ejder Yildirim; Ozturk Ozdemir; Ibrahim Akkurt
Journal:  Mol Biol Rep       Date:  2010-06-08       Impact factor: 2.316

2.  Methylenetetrahydrofolate reductase polymorphism and minor increase of risk for oral cancer.

Authors:  E Vairaktaris; C Yapijakis; P Kessler; A Vylliotis; J Ries; J Wiltfang; S Vassiliou; S Derka; F W Neukam
Journal:  J Cancer Res Clin Oncol       Date:  2005-12-20       Impact factor: 4.553

3.  International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants.

Authors:  Therese Truong; Wiebke Sauter; James D McKay; H Dean Hosgood; Carla Gallagher; Christopher I Amos; Margaret Spitz; Joshua Muscat; Philip Lazarus; Thomas Illig; H Erich Wichmann; Heike Bickeböller; Angela Risch; Hendrik Dienemann; Zuo-Feng Zhang; Behnaz Pezeshki Naeim; Ping Yang; Shanbeh Zienolddiny; Aage Haugen; Loïc Le Marchand; Yun-Chul Hong; Jin Hee Kim; Eric J Duell; Angeline S Andrew; Chikako Kiyohara; Hongbing Shen; Keitaro Matsuo; Takeshi Suzuki; Adeline Seow; Daniel P K Ng; Qing Lan; David Zaridze; Neonilia Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Vali Constantinescu; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Neil E Caporaso; Demetrius Albanes; Michael Thun; Maria Teresa Landi; Joanna Trubicka; Marcin Lener; Jan Lubinski; Ying Wang; Amélie Chabrier; Paolo Boffetta; Paul Brennan; Rayjean J Hung
Journal:  Carcinogenesis       Date:  2010-01-27       Impact factor: 4.944

4.  Quantitative assessment of the effect of MTHFR polymorphisms on the risk of lung carcinoma.

Authors:  Yao Zhang; Guo Qiang Chen; Yong Ji; Bin Huang; Wei Sheng Shen; Li Chun Deng; Lei Xi; Xiang Ming Cao
Journal:  Mol Biol Rep       Date:  2012-01-04       Impact factor: 2.316

5.  Methylenetetrahydrofolate reductase gene polymorphisms and lung cancer: a meta-analysis.

Authors:  Renfang Mao; Yihui Fan; Yan Jin; Jing Bai; Songbin Fu
Journal:  J Hum Genet       Date:  2008-03-14       Impact factor: 3.172

6.  MTHFR C677 T gene polymorphism in lymphoproliferative diseases.

Authors:  Ugur Deligezer; Ebru E Akisik; Fulya Yaman; Nilgün Erten; Nejat Dalay
Journal:  J Clin Lab Anal       Date:  2006       Impact factor: 2.352

7.  No association of the MTHFR gene A1298C polymorphism with the risk of prostate cancer: A meta-analysis.

Authors:  Dawei Li; Tian Tian; Chunhui Guo; Juchao Ren; Lei Yan; Hainan Liu; Zhonghua Xu
Journal:  Exp Ther Med       Date:  2012-01-04       Impact factor: 2.447

8.  Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and the risk of primary hepatocellular carcinoma (HCC) in a Chinese population.

Authors:  Li-Na Mu; Wei Cao; Zuo-Feng Zhang; Lin Cai; Qing-Wu Jiang; Nai-Chieh You; Binh Yang Goldstein; Guo-Rong Wei; Chuan-Wei Chen; Qing-Yi Lu; Xue-Fu Zhou; Bao-Guo Ding; Jun Chang; Shun-Zhang Yu
Journal:  Cancer Causes Control       Date:  2007-05-15       Impact factor: 2.506

9.  Meta-analysis on MTHFR polymorphism and lung cancer susceptibility in East Asian populations.

Authors:  Xue-DE Zhang; Yan-Ting Li; Shuan-Ying Yang; Wei Li
Journal:  Biomed Rep       Date:  2013-02-25

10.  Methylenetetrahydrofolate reductase C677T polymorphism in patients with lung cancer in a Korean population.

Authors:  Lian-Hua Cui; Min-Ho Shin; Hee Nam Kim; Hye-Rim Song; Jin-Mei Piao; Sun-Seog Kweon; Jin-Su Choi; Woo-Jun Yun; Young-Chul Kim; In-Jae Oh; Kyu-Sik Kim
Journal:  BMC Med Genet       Date:  2011-02-22       Impact factor: 2.103
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