Literature DB >> 12883553

Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits.

Thomas Blank1, Ingrid Nijholt, Min-Jeong Kye, Jelena Radulovic, Joachim Spiess.   

Abstract

Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is correlated with substantial changes in neuronal signal processing in the hippocampus. Here we show that elevated expression of small-conductance Ca2+-activated K+ channels (SK channels) of the SK3 type in hippocampi of aged mice contributes to reduced long-term potentiation (LTP) and impaired trace fear conditioning, a hippocampus-dependent learning task.

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Year:  2003        PMID： 12883553     DOI： 10.1038/nn1101

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  45 in total

1.  Acute stress facilitates trace eyeblink conditioning in C57BL/6 male mice and increases the excitability of their CA1 pyramidal neurons.

Authors:  Craig Weiss; Evgeny Sametsky; Astrid Sasse; Joachim Spiess; John F Disterhoft
Journal:  Learn Mem       Date:  2005 Mar-Apr       Impact factor: 2.460

2.  Metaplastic effect of apamin on LTP and paired-pulse facilitation.

Authors:  Laurence Ris; Brigitte Capron; Coralie Sclavons; Jean-François Liégeois; Vincent Seutin; Emile Godaux
Journal:  Learn Mem       Date:  2007-06-05       Impact factor: 2.460

3.  Dendritic spikes induce single-burst long-term potentiation.

Authors:  Stefan Remy; Nelson Spruston
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-16       Impact factor: 11.205

4.  Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice.

Authors:  Catherine C Kaczorowski; John F Disterhoft
Journal:  Learn Mem       Date:  2009-05-23       Impact factor: 2.460

Review 5.  Learning to learn - intrinsic plasticity as a metaplasticity mechanism for memory formation.

Authors:  Megha Sehgal; Chenghui Song; Vanessa L Ehlers; James R Moyer
Journal:  Neurobiol Learn Mem       Date:  2013-07-18       Impact factor: 2.877

Review 6.  The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases.

Authors:  Jenny Lam; Nichole Coleman; April Lourdes A Garing; Heike Wulff
Journal:  Expert Opin Ther Targets       Date:  2013-07-25       Impact factor: 6.902

Review 7.  Potassium channels: newly found players in synaptic plasticity.

Authors:  Jinhyun Kim; Dax A Hoffman
Journal:  Neuroscientist       Date:  2008-04-15       Impact factor: 7.519

8.  New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.

Authors:  Nichole Coleman; Brandon M Brown; Aida Oliván-Viguera; Vikrant Singh; Marilyn M Olmstead; Marta Sofia Valero; Ralf Köhler; Heike Wulff
Journal:  Mol Pharmacol       Date:  2014-06-23       Impact factor: 4.436

9.  Contextual memory deficits observed in mice overexpressing small conductance Ca2+-activated K+ type 2 (KCa2.2, SK2) channels are caused by an encoding deficit.

Authors:  Robert W Stackman; Chris T Bond; John P Adelman
Journal:  Learn Mem       Date:  2008-03-27       Impact factor: 2.460

10.  Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol.

Authors:  Sudarat Nimitvilai; Marcelo F Lopez; Patrick J Mulholland; John J Woodward
Journal:  Neuropsychopharmacology       Date:  2015-08-09       Impact factor: 7.853
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