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Literature DB >> 12882623

Growth hormone-releasing hormone and extra-pituitary tumorigenesis: therapeutic and diagnostic applications of growth hormone-releasing hormone antagonists.

Hippokratis Kiaris¹, Michael Koutsilieris, Anastasios Kalofoutis, Andrew V Schally.

Abstract

Growth hormone-releasing hormone (GHRH) regulates growth hormone release from the pituitary. However, in addition to this neuroendocrine action, much evidence implies an additional role for GHRH in carcinogenesis in non-pituitary tissues. This role of GHRH in cancer development appears to be due to the operation of several mechanisms, which involve the regulation of the growth hormone-dependent hepatic insulin-like growth factor I (IGFI) production, tumoural IGF-I and IGF-II secretion and direct action of GHRH on tumour cells by autocrine and/or paracrine pathways. This review summarises the available information regarding the role of GHRH in tumorigenesis with special emphasis on the direct action of GHRH in primary and experimental cancers.

Entities: Disease Gene

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Year: 2003 PMID： 12882623 DOI： 10.1517/13543784.12.8.1385

Source DB: PubMed Journal: Expert Opin Investig Drugs ISSN： 1354-3784 Impact factor: 6.206

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Cited

10 in total

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Journal: J Cancer Res Clin Oncol Date: 2011-12-08 Impact factor: 4.553

2. Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases.

Authors: Ferenc G Rick; Andrew V Schally; Luca Szalontay; Norman L Block; Karoly Szepeshazi; Mehrdad Nadji; Marta Zarandi; Florian Hohla; Stefan Buchholz; Stephan Seitz
Journal: Proc Natl Acad Sci U S A Date: 2012-01-18 Impact factor: 11.205

3. Antagonist of growth hormone-releasing hormone induces apoptosis in LNCaP human prostate cancer cells through a Ca2+-dependent pathway.

Authors: Zoltan Rekasi; Tamas Czompoly; Andrew V Schally; Ferenc Boldizsar; Jozsef L Varga; Marta Zarandi; Timea Berki; Reka A Horvath; Peter Nemeth
Journal: Proc Natl Acad Sci U S A Date: 2005-02-22 Impact factor: 11.205

4. Stimulation of proliferation of MCF-7 breast cancer cells by a transfected splice variant of growth hormone-releasing hormone receptor.

Authors: Nektarios Barabutis; Erasmia Tsellou; Andrew V Schally; Stavroula Kouloheri; Anastasios Kalofoutis; Hippokratis Kiaris
Journal: Proc Natl Acad Sci U S A Date: 2007-03-19 Impact factor: 11.205

5. Acceleration of wound healing by growth hormone-releasing hormone and its agonists.

Authors: Nikolina Dioufa; Andrew V Schally; Ioulia Chatzistamou; Evi Moustou; Norman L Block; Gary K Owens; Athanasios G Papavassiliou; Hippokratis Kiaris
Journal: Proc Natl Acad Sci U S A Date: 2010-10-11 Impact factor: 11.205

6. The immunohistochemical expression of growth hormone-releasing hormone receptor splice variant 1 is a favorable prognostic marker in colorectal cancer.

Authors: Elena Theophanous; Constantina Petraki; Andreas Scorilas; Vassilios Komborozos; George Veloudis; Jozsef L Varga; Marta Zarandi; Andrew V Schally; Michael Koutsilieris
Journal: Mol Med Date: 2009-04-15 Impact factor: 6.354

10. Tumorigenic transformation of human prostatic epithelial cell line RWPE-1 by growth hormone-releasing hormone (GHRH).

Authors: Laura Muñoz-Moreno; M José Carmena; Juan C Prieto; Andrew V Schally; Ana M Bajo
Journal: Prostate Date: 2022-03-24 Impact factor: 4.012