Literature DB >> 12882544

Enhanced production of recombinant B-domain deleted factor VIII from Chinese hamster ovary cells by propionic and butyric acids.

Bok-Hwan Chun1, Song-Yong Park, Namhyun Chung, Won-Gi Bang.   

Abstract

Sodium propionate, as well as sodium butyrate, enhanced the production of recombinant B-domain-deleted, factor VIII (rFVIIIdB) by Chinese hamster ovary cells growing in a spinner-flask with a protein-free medium by more than six-fold. The two acids, however, had different cytotoxicities.

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Year:  2003        PMID： 12882544     DOI： 10.1023/a:1022301528118

Source DB:  PubMed          Journal:  Biotechnol Lett        ISSN： 0141-5492            Impact factor:   2.461


  7 in total

1.  Using cell engineering and omic tools for the improvement of cell culture processes.

Authors:  Darrin Kuystermans; Britta Krampe; Halina Swiderek; Mohamed Al-Rubeai
Journal:  Cytotechnology       Date:  2007-02-24       Impact factor: 2.058

2.  Modulation of heparan sulfate biosynthesis by sodium butyrate in recombinant CHO cells.

Authors:  Payel Datta; Bo Yang; Robert J Linhardt; Susan T Sharfstein
Journal:  Cytotechnology       Date:  2014-01-29       Impact factor: 2.058

3.  Transient expression of human antibodies in mammalian cells.

Authors:  Rodrigo Vazquez-Lombardi; Damien Nevoltris; Ansha Luthra; Peter Schofield; Carsten Zimmermann; Daniel Christ
Journal:  Nat Protoc       Date:  2017-12-14       Impact factor: 13.491

4.  Stable Expression of Recombinant Factor VIII in CHO Cells Using Methotrexate-Driven Transgene Amplification.

Authors:  N A Orlova; S V Kovnir; I I Vorobiev; A S Yuriev; A G Gabibov; A I Vorobiev
Journal:  Acta Naturae       Date:  2012-01       Impact factor: 1.845

5.  Efficacy, Safety, and Pharmacokinetics of Beroctocog Alfa in Patients Previously Treated for Hemophilia A.

Authors:  Shin Young Hyun; Seon Yang Park; Soon Yong Lee; Hoon Kook; Sang Hoon Paik; In-Jin Jang; Kun Soo Lee
Journal:  Yonsei Med J       Date:  2015-07       Impact factor: 2.759

6.  Stable high-level expression of factor VIII in Chinese hamster ovary cells in improved elongation factor-1 alpha-based system.

Authors:  Nadezhda A Orlova; Sergey V Kovnir; Alexandre G Gabibov; Ivan I Vorobiev
Journal:  BMC Biotechnol       Date:  2017-03-24       Impact factor: 2.563

7.  Blood Clotting Factor VIII: From Evolution to Therapy.

Authors:  N A Orlova; S V Kovnir; I I Vorobiev; A G Gabibov; A I Vorobiev
Journal:  Acta Naturae       Date:  2013-04       Impact factor: 1.845
  7 in total

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