Brain abscess in children.

Brain abscess is a relatively uncommon but life-threatening infection in children. It can originate from contiguous site infections (eg, chronic otitis media, mastoiditis, sinusitis, meningitis), from distant pathologic states (eg, cyanotic congenital heart disease, chronic lung infections), after head trauma or neurosurgical procedures, or from cryptogenic sources. Predominant etiologic microorganisms vary depending on these predisposing factors. Computed tomography and magnetic resonance imaging are essential tools that enable the physician to make an accurate diagnosis of intracranial purulent collections. Proper selection of antimicrobial agents with good penetration of the central nervous system and with adequate coverage of both anaerobic and aerobic bacteria is critical for the medical management of brain abscess. Delay in surgical drainage can be associated with high morbidity and case-fatality rates. In the early phase of cerebritis, however, infection can respond to antibiotic therapy alone. Advances in diagnostic and therapeutic modalities during the last decade have improved the prognosis of this serious disease. Copyright 2003 Elsevier Inc. All rights reserved.