OBJECTIVE: To investigate the inflammatory and cellular response attributed to conventional cardiotomy suction vs cell-saver during cardiac surgery. DESIGN:Thirty-three (n = 33) low-risk patients admitted for routine coronary artery bypass grafting were randomly assigned to two groups: cardiotomy suction or cell-saver for salvage of pericardial blood. The groups were compared with reference to proinflammatory cytokines, complement activation, leukocyte pattern, and haemolysis during and after cardiopulmonary bypass. RESULTS: Pericardial suction blood contained significantly increased concentrations of free plasma haemoglobin, C3a, IL-6, IL-8, TNF-alpha, eosinophils and basophils compared with the systemic circulation. No differences were found for the terminal complement complex and lymphocytes, whereas overall concentrations of leukocytes, platelets and haemoglobin were decreased. Recycling of pericardial suction blood gave no systemic effects except from that of free plasma haemoglobin, which increased significantly. The cell-saver eliminated plasma haemoglobin, but no other effects could be demonstrated. CONCLUSION:Cardiotomy suction is a major cause of haemolysis, but contributes insignificantly to the systemic inflammatory response. Treatment of shed mediastinal blood with a cell-saver reduces haemolysis and may lower the dose load of inflammatory components.
RCT Entities:
OBJECTIVE: To investigate the inflammatory and cellular response attributed to conventional cardiotomy suction vs cell-saver during cardiac surgery. DESIGN: Thirty-three (n = 33) low-risk patients admitted for routine coronary artery bypass grafting were randomly assigned to two groups: cardiotomy suction or cell-saver for salvage of pericardial blood. The groups were compared with reference to proinflammatory cytokines, complement activation, leukocyte pattern, and haemolysis during and after cardiopulmonary bypass. RESULTS: Pericardial suction blood contained significantly increased concentrations of free plasma haemoglobin, C3a, IL-6, IL-8, TNF-alpha, eosinophils and basophils compared with the systemic circulation. No differences were found for the terminal complement complex and lymphocytes, whereas overall concentrations of leukocytes, platelets and haemoglobin were decreased. Recycling of pericardial suction blood gave no systemic effects except from that of free plasma haemoglobin, which increased significantly. The cell-saver eliminated plasma haemoglobin, but no other effects could be demonstrated. CONCLUSION: Cardiotomy suction is a major cause of haemolysis, but contributes insignificantly to the systemic inflammatory response. Treatment of shed mediastinal blood with a cell-saver reduces haemolysis and may lower the dose load of inflammatory components.
Authors: Joshua R Pohlmann; John M Toomasian; Claire E Hampton; Keith E Cook; Gail M Annich; Robert H Bartlett Journal: ASAIO J Date: 2009 Sep-Oct Impact factor: 2.872
Authors: Gerwin E Engels; Jan van Klarenbosch; Y John Gu; Willem van Oeveren; Adrianus J de Vries Journal: Interact Cardiovasc Thorac Surg Date: 2015-12-23
Authors: Alessandro Varrica; Angela Satriano; Alessandro Frigiola; Alessandro Giamberti; Guido Tettamanti; Luigi Anastasia; Erika Conforti; Antonio D W Gavilanes; Luc J Zimmermann; Hans J S Vles; Giovanni Li Volti; Diego Gazzolo Journal: Biomed Res Int Date: 2015-08-31 Impact factor: 3.411