C H Møller1, D A Steinbrüchel. 1. Department of Cardiothoracic Surgery, Rigshospitalet, University of Copenhagen, Denmark. chm@stud.ku.dk
Abstract
OBJECTIVE: After off-pump coronary artery bypass (OPCAB) haemostasis might be better preserved compared with on-pump coronary artery bypass grafting (CABG). The aim of this study was to investigate whether this possibly better preserved haemostasis results in a procoagulant activity of the platelets. DESIGN: Thirty patients were studied prospectively, 15 undergoing on-pump CABG and 15 undergoing OPCAB. Platelet function was evaluated four times within the first 24 h: preoperatively, postoperatively, 4 h and 1 day after surgery with a bedside whole blood clotting test. RESULTS: A significant increase of platelet-activating-factor-induced platelet aggregation was observed postoperatively after OPCAB (p < 0.01). Only two patients did not reach preoperative values within 1 day postoperatively and four patients had a more than twofold increase. Platelet aggregation immediately after on-pump CABG was reduced to near half of preoperative values, but within 1 day postoperatively normal platelet aggregation was regained in half of the patients. CONCLUSION: This study has mainly indicated that platelets after OPCAB were more easily activated in the early postoperative period. After CABG with cardiopulmonary bypass we found a temporary platelet dysfunction which seemed to be overcome within the first postoperative day.
OBJECTIVE: After off-pump coronary artery bypass (OPCAB) haemostasis might be better preserved compared with on-pump coronary artery bypass grafting (CABG). The aim of this study was to investigate whether this possibly better preserved haemostasis results in a procoagulant activity of the platelets. DESIGN: Thirty patients were studied prospectively, 15 undergoing on-pump CABG and 15 undergoing OPCAB. Platelet function was evaluated four times within the first 24 h: preoperatively, postoperatively, 4 h and 1 day after surgery with a bedside whole blood clotting test. RESULTS: A significant increase of platelet-activating-factor-induced platelet aggregation was observed postoperatively after OPCAB (p < 0.01). Only two patients did not reach preoperative values within 1 day postoperatively and four patients had a more than twofold increase. Platelet aggregation immediately after on-pump CABG was reduced to near half of preoperative values, but within 1 day postoperatively normal platelet aggregation was regained in half of the patients. CONCLUSION: This study has mainly indicated that platelets after OPCAB were more easily activated in the early postoperative period. After CABG with cardiopulmonary bypass we found a temporary platelet dysfunction which seemed to be overcome within the first postoperative day.
Authors: Louise Bochsen; Lisbeth Bredahl Rosengaard; Allan Bybeck Nielsen; Daniel A Steinbrüchel; Pär I Johansson Journal: J Extra Corpor Technol Date: 2009-03
Authors: Robert S Poston; Junyan Gu; Charles White; Jean Jeudy; Lei Nie; James Brown; James Gammie; Richard N Pierson; Linda Romar; Bartley P Griffith Journal: Transfusion Date: 2008-03 Impact factor: 3.157
Authors: Paulo Roberto L Prates; Judson B Williams; Rajendra H Mehta; Susanna R Stevens; Laine Thomas; Peter K Smith; L Kristin Newby; Renato A K Kalil; John H Alexander; Renato D Lopes Journal: Braz J Cardiovasc Surg Date: 2016-04