Gabrielle A Carlson1, Kevin L Kelly. 1. Department of Psychiatry and Behavioral Science, State University of New York at Stony Brook, Stony Brook, New York 11794-8790, USA.
Abstract
OBJECTIVE: To examine rates and implications of stimulant-induced rebound - the behavioral deterioration that may occur as stimulant medications wear off. METHODS: This study compares nurse observations on evening shifts compared to day shifts in 149 psychiatrically hospitalized children treated with short-acting stimulants, usually methylphenidate, comparing nonmedication and stimulant-treated states. RESULTS: Behavioral deterioration (rebound), was observed in 30% of children on at least one dose of stimulants but was serious enough to discontinue treatment in only 8.7%. Children experiencing rebound did not differ clinically from those who did not. CONCLUSIONS: Rebound exists, occurs significantly in less than 10% of psychiatrically hospitalized children with attention deficit hyperactivity disorder, and does not appear to have specific diagnostic significance.
OBJECTIVE: To examine rates and implications of stimulant-induced rebound - the behavioral deterioration that may occur as stimulant medications wear off. METHODS: This study compares nurse observations on evening shifts compared to day shifts in 149 psychiatrically hospitalized children treated with short-acting stimulants, usually methylphenidate, comparing nonmedication and stimulant-treated states. RESULTS:Behavioral deterioration (rebound), was observed in 30% of children on at least one dose of stimulants but was serious enough to discontinue treatment in only 8.7%. Children experiencing rebound did not differ clinically from those who did not. CONCLUSIONS: Rebound exists, occurs significantly in less than 10% of psychiatrically hospitalized children with attention deficit hyperactivity disorder, and does not appear to have specific diagnostic significance.
Authors: Atilla Turgay; Lawrence Ginsberg; Elias Sarkis; Rakesh Jain; Ben Adeyi; Joseph Gao; Bryan Dirks; Thomas Babcock; Brian Scheckner; Cynthia Richards; Robert Lasser; Robert L Findling Journal: J Child Adolesc Psychopharmacol Date: 2010-12 Impact factor: 2.576
Authors: Annette Conzelmann; Eva Woidich; Ronald F Mucha; Peter Weyers; Mathias Müller; Klaus-Peter Lesch; Christian P Jacob; Paul Pauli Journal: J Neural Transm (Vienna) Date: 2016-02-06 Impact factor: 3.575