Megan C Lisska1, Scott A Rivkees. 1. Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA.
Abstract
OBJECTIVE: The use of methylphenidate (Ritalin) for treatment of attention deficit/hyperactivity disorder (ADHD) has increased dramatically over the last decade. However, the influence of methylphenidate on growth remains controversial. Our goals were to assess whether methylphenidate, as prescribed in the community setting, influences growth. DESIGN: We examined the growth of 84 patients with ADHD treated with methylphenidate in two large pediatric practices. Height standard deviation (SD) scores of treated children were compared with those of untreated biological siblings. We also analyzed the doses of methylphenidate in relation to changes in growth. RESULTS: We found significant differences in mean height SD scores between treated children and sibling controls after 2 years of treatment. Effects on growth were observed over the broad range of doses used (10-80 mg per day). CONCLUSIONS: Our findings suggest that the prevalence of grow-suppressive effects of methylphenidate is greater than previously suspected.
OBJECTIVE: The use of methylphenidate (Ritalin) for treatment of attention deficit/hyperactivity disorder (ADHD) has increased dramatically over the last decade. However, the influence of methylphenidate on growth remains controversial. Our goals were to assess whether methylphenidate, as prescribed in the community setting, influences growth. DESIGN: We examined the growth of 84 patients with ADHD treated with methylphenidate in two large pediatric practices. Height standard deviation (SD) scores of treated children were compared with those of untreated biological siblings. We also analyzed the doses of methylphenidate in relation to changes in growth. RESULTS: We found significant differences in mean height SD scores between treated children and sibling controls after 2 years of treatment. Effects on growth were observed over the broad range of doses used (10-80 mg per day). CONCLUSIONS: Our findings suggest that the prevalence of grow-suppressive effects of methylphenidate is greater than previously suspected.
Authors: Elizabeth Pappadopulos; Sophie Woolston; Alanna Chait; Matthew Perkins; Daniel F Connor; Peter S Jensen Journal: J Can Acad Child Adolesc Psychiatry Date: 2006-02
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