BACKGROUND: Urinary tract infection is a frequent bacterial complication after renal transplantation in adults and children, however there are only very limited data on children beyond the early post-transplant period. In this study we investigated urinary tract infections in pediatric outpatients who had received transplants more than six months previously. Incidence, risk factors and impact on short-term graft function were analyzed. METHODS: 47 children who had received a total of 58 allografts were analyzed between 1997 and 2000. At the time of analysis they had had their transplants for an average of 3.5 years (range 0.5-9.4). Urinary tract infection was defined as the presence of both significant bacteriuria (> 10(5) CFU/ml) and symptoms. RESULTS: Of the 47 patients, 15 (32%) had from 1 to 7 urinary tract infections each. In total 35 infections were recorded. Median age at urinary tract infection was 5.5 years (range 1.8-24.2). Gender, donor source, immunosuppression and underlying disease (urologic vs non-urologic) did not influence the incidence of urinary tract infection. Creatinine but not C-reactive protein rose significantly during the infection. CONCLUSIONS: Our data suggest that urinary tract infection remains a frequent but mostly benign complication in the pediatric transplant population, even beyond the early post-transplant period. More extended studies are needed to assess the long-term effects on graft function.
BACKGROUND:Urinary tract infection is a frequent bacterial complication after renal transplantation in adults and children, however there are only very limited data on children beyond the early post-transplant period. In this study we investigated urinary tract infections in pediatric outpatients who had received transplants more than six months previously. Incidence, risk factors and impact on short-term graft function were analyzed. METHODS: 47 children who had received a total of 58 allografts were analyzed between 1997 and 2000. At the time of analysis they had had their transplants for an average of 3.5 years (range 0.5-9.4). Urinary tract infection was defined as the presence of both significant bacteriuria (> 10(5) CFU/ml) and symptoms. RESULTS: Of the 47 patients, 15 (32%) had from 1 to 7urinary tract infections each. In total 35 infections were recorded. Median age at urinary tract infection was 5.5 years (range 1.8-24.2). Gender, donor source, immunosuppression and underlying disease (urologic vs non-urologic) did not influence the incidence of urinary tract infection. Creatinine but not C-reactive protein rose significantly during the infection. CONCLUSIONS: Our data suggest that urinary tract infection remains a frequent but mostly benign complication in the pediatric transplant population, even beyond the early post-transplant period. More extended studies are needed to assess the long-term effects on graft function.
Authors: M Spielberger; T Schmid; P Sandbichler; H Pernthaler; C Bösmüller; E Semenitz; R Margreiter Journal: Wien Klin Wochenschr Date: 1989-03-31 Impact factor: 1.704
Authors: W Rowiński; M Pacholczyk; A Chmura; S Cajzner; M Lao; J Kowalczyk; B Lagiewska; J Wałaszewski Journal: Transplant Proc Date: 1991-10 Impact factor: 1.066
Authors: N Goya; K Tanabe; Y Iguchi; T Oshima; T Yagisawa; H Toma; T Agishi; K Ota; K Takahashi Journal: Infection Date: 1997 Mar-Apr Impact factor: 3.553
Authors: E Renoult; F Aouragh; D Mayeux; D Hestin; A Lataste; J Hubert; J L'Hermite; M Weber; M Kessler Journal: Transplant Proc Date: 1994-08 Impact factor: 1.066
Authors: Friederike Weigel; Anja Lemke; Burkhard Tönshoff; Lars Pape; Henry Fehrenbach; Michael Henn; Bernd Hoppe; Therese Jungraithmayr; Martin Konrad; Guido Laube; Martin Pohl; Tomáš Seeman; Hagen Staude; Markus J Kemper; Ulrike John Journal: Pediatr Nephrol Date: 2016-01-11 Impact factor: 3.714