OBJECTIVE: To study the relationship between cytokine levels and cardiac troponin I (cTnI). DESIGN: Prospective experimental study. SETTING: Intensive care unit of a university hospital. PARTICIPANTS: Six healthy male volunteers. INTERVENTIONS. Endotoxin, 4 ng/kg, was given as a 1-min intravenous infusion. MEASUREMENTS AND RESULTS: Circulating cardiac troponin I levels and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were analysed at various time points during a 24-h period. TNF-alpha appeared in the circulation 30 min after injection (T=0.5 h), reaching peak levels (5,665+/-1,910 pg/ml) 2 h after infusion. At T=24 h TNF-alpha was still elevated in the circulation compared to T=0. None of the six volunteers had a cTnI value higher than 0.1 microg/l at T=0, 6 h or 24 h. CONCLUSION: The presence of significant amounts of TNF-alpha, IL-6 and IL-8 in the systemic circulation does not lead to increased levels of cTnI in experimental human endotoxaemia.
OBJECTIVE: To study the relationship between cytokine levels and cardiac troponin I (cTnI). DESIGN: Prospective experimental study. SETTING: Intensive care unit of a university hospital. PARTICIPANTS: Six healthy male volunteers. INTERVENTIONS. Endotoxin, 4 ng/kg, was given as a 1-min intravenous infusion. MEASUREMENTS AND RESULTS: Circulating cardiac troponin I levels and proinflammatory cytokines tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were analysed at various time points during a 24-h period. TNF-alpha appeared in the circulation 30 min after injection (T=0.5 h), reaching peak levels (5,665+/-1,910 pg/ml) 2 h after infusion. At T=24 h TNF-alpha was still elevated in the circulation compared to T=0. None of the six volunteers had a cTnI value higher than 0.1 microg/l at T=0, 6 h or 24 h. CONCLUSION: The presence of significant amounts of TNF-alpha, IL-6 and IL-8 in the systemic circulation does not lead to increased levels of cTnI in experimental human endotoxaemia.
Authors: J E Adams; G S Bodor; V G Dávila-Román; J A Delmez; F S Apple; J H Ladenson; A S Jaffe Journal: Circulation Date: 1993-07 Impact factor: 29.690
Authors: Helge Røsjø; Marjut Varpula; Tor-Arne Hagve; Sari Karlsson; Esko Ruokonen; Ville Pettilä; Torbjørn Omland Journal: Intensive Care Med Date: 2010-10-12 Impact factor: 17.440
Authors: Richard J Kovacs; Giuliana Maldonado; Analia Azaro; Maria S Fernández; Federico L Romero; Juan M Sepulveda-Sánchez; Mary Corretti; Michael Carducci; Melda Dolan; Ivelina Gueorguieva; Ann L Cleverly; N Sokalingum Pillay; Jose Baselga; Michael M Lahn Journal: Cardiovasc Toxicol Date: 2015-10 Impact factor: 3.231