BACKGROUND: A low level of response (LR) to alcohol seems to relate to a substantial proportion of the risk for alcoholism and to have significant heritability. METHODS: This report describes the results of a genome-wide segregation analysis for the first 139 pairs of full siblings by using an alcohol challenge protocol as a direct measure of LR. Subjects from 18 to 29 years old were selected if the original screen indicated they had an alcohol-dependent parent, reported a personal history of drinking but had no evidence of alcohol dependence, and had a full sibling with similar characteristics. Body sway and Subjective High Assessment Scale scores were measured at baseline and at regular intervals after the administration of a measured dose of alcohol. Participants and available parents were genotyped for 811 microsatellite markers, and resulting data were analyzed with a variance component method. RESULTS: Nine chromosome regions with logarithm of the odds ratio (LOD) between 2.2 and 3.2 were identified; several had previously been implicated regarding phenotypes relevant to alcoholism and the LR to alcohol. Several regions identified in the previous linkage study by using a retrospective self-report questionnaire were potentially confirmed by this study. The strongest evidence was on chromosomes 10, 11, and 22. CONCLUSIONS: Several chromosomal areas seem to relate to the low LR to alcohol as a risk factor for alcohol dependence.
BACKGROUND: A low level of response (LR) to alcohol seems to relate to a substantial proportion of the risk for alcoholism and to have significant heritability. METHODS: This report describes the results of a genome-wide segregation analysis for the first 139 pairs of full siblings by using an alcohol challenge protocol as a direct measure of LR. Subjects from 18 to 29 years old were selected if the original screen indicated they had an alcohol-dependent parent, reported a personal history of drinking but had no evidence of alcohol dependence, and had a full sibling with similar characteristics. Body sway and Subjective High Assessment Scale scores were measured at baseline and at regular intervals after the administration of a measured dose of alcohol. Participants and available parents were genotyped for 811 microsatellite markers, and resulting data were analyzed with a variance component method. RESULTS: Nine chromosome regions with logarithm of the odds ratio (LOD) between 2.2 and 3.2 were identified; several had previously been implicated regarding phenotypes relevant to alcoholism and the LR to alcohol. Several regions identified in the previous linkage study by using a retrospective self-report questionnaire were potentially confirmed by this study. The strongest evidence was on chromosomes 10, 11, and 22. CONCLUSIONS: Several chromosomal areas seem to relate to the low LR to alcohol as a risk factor for alcohol dependence.
Authors: Geoff Joslyn; Gerry Brush; Margaret Robertson; Tom L Smith; Jelger Kalmijn; Marc Schuckit; Raymond L White Journal: Proc Natl Acad Sci U S A Date: 2008-12-08 Impact factor: 11.205
Authors: Cindy L Ehlers; Ian R Gizer; David A Gilder; Kirk C Wilhelmsen Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2011-08-02 Impact factor: 3.568
Authors: Trina M Norden-Krichmar; Ian R Gizer; Ondrej Libiger; Kirk C Wilhelmsen; Cindy L Ehlers; Nicholas J Schork Journal: Am J Hum Biol Date: 2014-02-17 Impact factor: 1.937
Authors: Cindy L Ehlers; David A Gilder; Wendy S Slutske; Penelope A Lind; Kirk C Wilhelmsen Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2008-09-05 Impact factor: 3.568