BACKGROUND: Saccadic latency may provide an objective method to assess sedative doses of anaesthetic on cortical oculomotor mechanisms and decision making. METHODS: We tested the effects of random doses of 0, 0.1, 0.2 and 0.3 MAC sevoflurane in six subjects, in a double-blind study using two measures of behavioural impairment: saccadic latency and stop signal reaction time (SSRT) in a countermanding task. RESULTS:Saccadic latency and SSRT both increased with increasing doses of sevoflurane. In both measures, reciprocal reaction time was linearly related to dose in each subject: all but two of the twelve regression coefficients were statistically significant (P<0.05). In one subject, SSRT was significantly more sensitive than simple latency (P<0.05); for the others there was no significant difference. CONCLUSION: Measurements of this kind could potentially provide estimates of cortical effects of sevoflurane sedation, and give a clinically useful measure of cognitive fitness.
RCT Entities:
BACKGROUND: Saccadic latency may provide an objective method to assess sedative doses of anaesthetic on cortical oculomotor mechanisms and decision making. METHODS: We tested the effects of random doses of 0, 0.1, 0.2 and 0.3 MAC sevoflurane in six subjects, in a double-blind study using two measures of behavioural impairment: saccadic latency and stop signal reaction time (SSRT) in a countermanding task. RESULTS: Saccadic latency and SSRT both increased with increasing doses of sevoflurane. In both measures, reciprocal reaction time was linearly related to dose in each subject: all but two of the twelve regression coefficients were statistically significant (P<0.05). In one subject, SSRT was significantly more sensitive than simple latency (P<0.05); for the others there was no significant difference. CONCLUSION: Measurements of this kind could potentially provide estimates of cortical effects of sevoflurane sedation, and give a clinically useful measure of cognitive fitness.
Authors: Florian Krismer; Jonathan C P Roos; Melanie Schranz; Ivo W Graziadei; Sergei Mechtcheriakov; Wolfgang Vogel; R H S Carpenter; Heinz Zoller Journal: Metab Brain Dis Date: 2010-09-18 Impact factor: 3.584
Authors: Chrystalina A Antoniades; Philip Buttery; James J FitzGerald; Roger A Barker; Roger H S Carpenter; Colin Watts Journal: PLoS One Date: 2012-03-12 Impact factor: 3.240