Literature DB >> 12876670

Survival signals in leukemic large granular lymphocytes.

P K Epling-Burnette1, Thomas P Loughran.   

Abstract

The central hypothesis of our laboratory research program in large granular lymphocyte (LGL) leukemia is that leukemic LGL represent antigen-driven cytotoxic T lymphocytes (CTL) with characteristics of dysregulated apoptosis. The clinical features of LGL leukemia highlight the association of autoimmune diseases such as rheumatoid arthritis with the T-cell form of LGL leukemia. We therefore used LGL leukemia as a model disease of dysregulated apoptosis leading to both malignant and autoimmune diseases. Here, we review our understanding of survival signals activated in leukemic LGL in the context of knowledge concerning apoptotic pathways in activated normal lymphocytes.

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Year:  2003        PMID： 12876670     DOI： 10.1016/s0037-1963(03)00135-5

Source DB:  PubMed          Journal:  Semin Hematol        ISSN： 0037-1963            Impact factor:   3.851


  15 in total

1.  Large granular lymphocyte disorders: new etiopathogenetic clues as a rationale for innovative therapeutic approaches.

Authors:  Renato Zambello; Gianpietro Semenzato
Journal:  Haematologica       Date:  2009-10       Impact factor: 9.941

2.  Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia.

Authors:  Michael J Clemente; Marcin W Wlodarski; Hideki Makishima; Aaron D Viny; Isabell Bretschneider; Mohammad Shaik; Nelli Bejanyan; Alan E Lichtin; Eric D Hsi; Eric D His; Ronald L Paquette; Thomas P Loughran; Jaroslaw P Maciejewski
Journal:  Blood       Date:  2011-08-24       Impact factor: 22.113

Review 3.  T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias.

Authors:  Rebecca J Watters; Xin Liu; Thomas P Loughran
Journal:  Leuk Lymphoma       Date:  2011-07-13

Review 4.  The spectrum of large granular lymphocyte leukemia and Felty's syndrome.

Authors:  Xin Liu; Thomas P Loughran
Journal:  Curr Opin Hematol       Date:  2011-07       Impact factor: 3.284

5.  Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia.

Authors:  Jun Yang; P K Epling-Burnette; Jeffrey S Painter; Jianxiang Zou; Fanqi Bai; Sheng Wei; Thomas P Loughran
Journal:  Blood       Date:  2007-11-09       Impact factor: 22.113

6.  A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia.

Authors:  Xianghong Chen; Fanqi Bai; Lubomir Sokol; Junmin Zhou; Amy Ren; Jeffrey S Painter; Jinhong Liu; David A Sallman; Y Ann Chen; Jeffrey A Yoder; Julie Y Djeu; Thomas P Loughran; Pearlie K Epling-Burnette; Sheng Wei
Journal:  Blood       Date:  2008-12-15       Impact factor: 22.113

7.  Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes.

Authors:  Mithun Vinod Shah; Ranran Zhang; Rosalyn Irby; Ravi Kothapalli; Xin Liu; Ty Arrington; Bryan Frank; Norman H Lee; Thomas P Loughran
Journal:  Blood       Date:  2008-05-13       Impact factor: 22.113

8.  Detection of monoclonal T populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells.

Authors:  Cristina Gattazzo; Antonella Teramo; Francesca Passeri; Elena De March; Samuela Carraro; Valentina Trimarco; Federica Frezzato; Tamara Berno; Gregorio Barilà; Veronica Martini; Francesco Piazza; Livio Trentin; Monica Facco; Gianpietro Semenzato; Renato Zambello
Journal:  Haematologica       Date:  2014-09-05       Impact factor: 9.941

9.  Phenotypic differences between healthy effector CTL and leukemic LGL cells support the notion of antigen-triggered clonal transformation in T-LGL leukemia.

Authors:  Marcin W Wlodarski; Zachary Nearman; Anna Jankowska; Nina Babel; Jennifer Powers; Patrick Leahy; Hans-Dieter Volk; Jaroslaw P Maciejewski
Journal:  J Leukoc Biol       Date:  2007-12-17       Impact factor: 4.962

Review 10.  Hematological malignancies escape from NK cell innate immune surveillance: mechanisms and therapeutic implications.

Authors:  Laure Farnault; Carole Sanchez; Céline Baier; Thérèse Le Treut; Régis T Costello
Journal:  Clin Dev Immunol       Date:  2012-08-01
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