Literature DB >> 12876464

Changes in ghrelin and ghrelin receptor expression according to feeding status.

Min-Seon Kim1, Cho-Ya Yoon, Kyeong-Han Park, Chan-Soo Shin, Kyong-Soo Park, Seong-Yeon Kim, Bo-Youn Cho, Hong-Kyu Lee.   

Abstract

Ghrelin, a newly identified gut hormone, has been implicated in the regulation of food intake and energy homeostasis. This study was undertaken to investigate changes in expression levels of stomach ghrelin as well as of ghrelin receptor in the hypothalamus and pituitary glands according to feeding state. Stomach ghrelin mRNA levels were increased by 48 h fasting but decreased by re-feeding. The ghrelin receptor mRNA levels of 48 h fasted rats were 8 times higher in the hypothalamus and 3 times higher in the anterior pituitary gland than levels in fed rats. In summary, not only stomach ghrelin, but also hypothalamic ghrelin receptor mRNA expression, increased during a fast. Such as enhanced ghrelin receptor expression could contribute to the amplification of ghrelin action in a negative-energy balance state.

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Year:  2003        PMID： 12876464     DOI： 10.1097/01.wnr.0000078703.79393.d2

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  46 in total

1.  Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity.

Authors:  Andrea Baessler; Michael J Hasinoff; Marcus Fischer; Wibke Reinhard; Gabriele E Sonnenberg; Michael Olivier; Jeanette Erdmann; Heribert Schunkert; Angela Doering; Howard J Jacob; Anthony G Comuzzie; Ahmed H Kissebah; Anne E Kwitek
Journal:  Diabetes       Date:  2005-01       Impact factor: 9.461

2.  NPY Y1 receptor is involved in ghrelin- and fasting-induced increases in foraging, food hoarding, and food intake.

Authors:  Erin Keen-Rhinehart; Timothy J Bartness
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2007-01-04       Impact factor: 3.619

3.  Intermittent Fasting Promotes Fat Loss With Lean Mass Retention, Increased Hypothalamic Norepinephrine Content, and Increased Neuropeptide Y Gene Expression in Diet-Induced Obese Male Mice.

Authors:  Juliet D Gotthardt; Jessica L Verpeut; Bryn L Yeomans; Jennifer A Yang; Ali Yasrebi; Troy A Roepke; Nicholas T Bello
Journal:  Endocrinology       Date:  2015-12-14       Impact factor: 4.736

4.  Growth hormone secretagogue receptor constitutive activity impairs voltage-gated calcium channel-dependent inhibitory neurotransmission in hippocampal neurons.

Authors:  Valentina Martínez Damonte; Silvia Susana Rodríguez; Jesica Raingo
Journal:  J Physiol       Date:  2018-10-14       Impact factor: 5.182

5.  Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity.

Authors:  Marcelo O Dietrich; Catiele Antunes; Gan Geliang; Zhong-Wu Liu; Erzsebet Borok; Yongzhan Nie; Allison W Xu; Diogo O Souza; Qian Gao; Sabrina Diano; Xiao-Bing Gao; Tamas L Horvath
Journal:  J Neurosci       Date:  2010-09-01       Impact factor: 6.167

6.  Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa.

Authors:  Andreas Stengel; Miriam Goebel; Iskandar Yakubov; Lixin Wang; Derrick Witcher; Tamer Coskun; Yvette Taché; George Sachs; Nils W G Lambrecht
Journal:  Endocrinology       Date:  2008-09-25       Impact factor: 4.736

7.  Role of Glucocorticoids in Fasting-induced Changes in Hypothalamic and Pituitary Components of the Growth Hormone (GH)-axis.

Authors:  Eunhee Kim; Sanghee Seo; Hyunju Chung; Seungjoon Park
Journal:  Korean J Physiol Pharmacol       Date:  2008-10-31       Impact factor: 2.016

8.  Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa.

Authors:  Andreas Stengel; Miriam Goebel; Lixin Wang; Yvette Taché; George Sachs; Nils W G Lambrecht
Journal:  Biochem Biophys Res Commun       Date:  2010-01-07       Impact factor: 3.575

9.  Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol.

Authors:  Ali Yasrebi; Anna Hsieh; Kyle J Mamounis; Elizabeth A Krumm; Jennifer A Yang; Jason Magby; Pu Hu; Troy A Roepke
Journal:  Mol Cell Endocrinol       Date:  2015-11-11       Impact factor: 4.102

10.  Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men.

Authors:  Jianhua Liu; Catherine E Prudom; Ralf Nass; Suzan S Pezzoli; Mary C Oliveri; Michael L Johnson; Paula Veldhuis; David A Gordon; Andrew D Howard; Derrick R Witcher; H Mario Geysen; Bruce D Gaylinn; Michael O Thorner
Journal:  J Clin Endocrinol Metab       Date:  2008-03-18       Impact factor: 5.958
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