D L Clarke1, A McKune, S R Thomson. 1. Department of General Surgery, Nelson R. Mandela School of Medicine, University of Natal, Private Bag 7, Congella, South Africa, 4013.
Abstract
BACKGROUND: The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF. METHODS: In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject. RESULTS: After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension. CONCLUSIONS: Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.
BACKGROUND: The vasoactive peptide octreotide has an established role in controlling variceal hemorrhage. The mechanism of action is believed to be a reduction in splanchnic blood flow. A decrease in splanchnic blood flow should be mirrored by a decrease in gastric mucosal blood flow (GMBF). Laser Doppler flowmetry (LDF) should detect changes in GMBF. METHODS: In seven normal volunteers and four patients with portal hypertension, 100 micro g of octreotide was administered as an intravenous bolus. Continuous LDF measurements were then made at a single point on the midantrum for at least 10 min and plotted against time for each subject. RESULTS: After a variable period of stabilization, GMBF decreased in all subjects except one. This was statistically significant in both the controls and the patients with portal hypertension. CONCLUSIONS:Octreotide decreases GMBF in normal and portal hypertensive stomachs. Laser Doppler is a useful and minimally invasive tool to assess the effect of drugs on GMBF.
Authors: M K Li; J J Sung; K S Woo; J Sanderson; N W Leung; L M Yu; C P Tsui; S C Chung; F W Leung Journal: Dig Dis Sci Date: 1996-12 Impact factor: 3.199
Authors: D Taranto; G Leonardo; F Beneduce; L M Vitale; C Loguercio; R Del Guercio; C Del Vecchio Blanco Journal: Digestion Date: 1997 Impact factor: 3.216