Literature DB >> 12873520

Pyrrolo[2,3-h]quinolinones: synthesis and photochemotherapic activity.

Paola Barraja1, Patrizia Diana, Antonino Lauria, Alessandra Montalbano, Anna Maria Almerico, Gaetano Dattolo, Girolamo Cirrincione, Giampietro Viola, Francesco Dall'Acqua.   

Abstract

A series of derivatives of the new ring system pyrrolo[2,3-h]quinoline-2-one was synthesized and evaluated as photoreagents toward cultured human tumor cells. Remarkable phototoxycity resulted for some derivatives, especially those bearing the phenyl group at the 7-position.

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Year:  2003        PMID： 12873520     DOI： 10.1016/s0960-894x(03)00529-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  3-Benzyl-7-methyl-9-phenyl-2-tosyl-2,3,3a,4,9,9a-hexa-hydro-1H-pyrrolo[3,4-b]quinoline.

Authors:  K Chinnakali; D Sudha; M Jayagobi; R Raghunathan; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-10-31

2.  3-[4-(1H-indol-3-yl)-1,3-thiazol-2-yl]-1H-pyrrolo[2,3-b]pyridines, nortopsentin analogues with antiproliferative activity.

Authors:  Barbara Parrino; Anna Carbone; Gloria Di Vita; Cristina Ciancimino; Alessandro Attanzio; Virginia Spanò; Alessandra Montalbano; Paola Barraja; Luisa Tesoriere; Maria Antonia Livrea; Patrizia Diana; Girolamo Cirrincione
Journal:  Mar Drugs       Date:  2015-04-03       Impact factor: 5.118

3.  Pyrrolo[2',3':3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types.

Authors:  Virginia Spanò; Roberta Rocca; Marilia Barreca; Daniele Giallombardo; Alessandra Montalbano; Anna Carbone; Maria Valeria Raimondi; Eugenio Gaudio; Roberta Bortolozzi; Ruoli Bai; Pierfrancesco Tassone; Stefano Alcaro; Ernest Hamel; Giampietro Viola; Francesco Bertoni; Paola Barraja
Journal:  J Med Chem       Date:  2020-10-11       Impact factor: 7.446
  3 in total

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