Literature DB >> 12873508

Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa.

Thomas E Renau1, Roger Léger, Lubov Filonova, Eric M Flamme, Michael Wang, Rose Yen, Deidre Madsen, David Griffith, Suzanne Chamberland, Michael N Dudley, Ving J Lee, Olga Lomovskaya, William J Watkins, Toshiharu Ohta, Kiyoshi Nakayama, Yohei Ishida.   

Abstract

Conformational restriction of the ornithine residue of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595, 2) furnished bioisosteric proline derivatives that were less toxic in vivo and as active as the lead in potentiating the activity of the fluoroquinolone levofloxacin via the inhibition of efflux pumps in Pseudomonas aeruginosa.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12873508     DOI： 10.1016/s0960-894x(03)00556-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  20 in total

1.  Advances in the structural studies of antibiotic potentiators against Escherichia coli.

Authors:  Gifty A Blankson; Ajit K Parhi; Malvika Kaul; Daniel S Pilch; Edmond J LaVoie
Journal:  Bioorg Med Chem       Date:  2019-06-04       Impact factor: 3.641

2.  Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It.

Authors:  Helen I Zgurskaya; Cesar A Löpez; S Gnanakaran
Journal:  ACS Infect Dis       Date:  2015       Impact factor: 5.084

Review 3.  The hydrophobic trap-the Achilles heel of RND efflux pumps.

Authors:  Zachary Aron; Timothy J Opperman
Journal:  Res Microbiol       Date:  2017-11-13       Impact factor: 3.992

Review 4.  Optimization of a novel series of pyranopyridine RND efflux pump inhibitors.

Authors:  Zachary Aron; Timothy J Opperman
Journal:  Curr Opin Microbiol       Date:  2016-05-24       Impact factor: 7.934

5.  Machine Learning Algorithm Identifies an Antibiotic Vocabulary for Permeating Gram-Negative Bacteria.

Authors:  Rachael A Mansbach; Inga V Leus; Jitender Mehla; Cesar A Lopez; John K Walker; Valentin V Rybenkov; Nicolas W Hengartner; Helen I Zgurskaya; S Gnanakaran
Journal:  J Chem Inf Model       Date:  2020-06-09       Impact factor: 4.956

6.  Inhibition of antibiotic efflux in bacteria by the novel multidrug resistance inhibitors biricodar (VX-710) and timcodar (VX-853).

Authors:  Steve Mullin; Nagraj Mani; Trudy H Grossman
Journal:  Antimicrob Agents Chemother       Date:  2004-11       Impact factor: 5.191

7.  Use of an efflux pump inhibitor to determine the prevalence of efflux pump-mediated fluoroquinolone resistance and multidrug resistance in Pseudomonas aeruginosa.

Authors:  Jane Kriengkauykiat; Edith Porter; Olga Lomovskaya; Annie Wong-Beringer
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

Review 8.  Microbial efflux pump inhibition: tactics and strategies.

Authors:  George P Tegos; Mark Haynes; J Jacob Strouse; Mohiuddin Md T Khan; Cristian G Bologa; Tudor I Oprea; Larry A Sklar
Journal:  Curr Pharm Des       Date:  2011       Impact factor: 3.116

Review 9.  Mycobacterium tuberculosis Major Facilitator Superfamily Transporters.

Authors:  Ping Li; Yinzhong Gu; Jiang Li; Longxiang Xie; Xue Li; Jianping Xie
Journal:  J Membr Biol       Date:  2017-08-29       Impact factor: 1.843

10.  A copper-activated two-component system interacts with zinc and imipenem resistance in Pseudomonas aeruginosa.

Authors:  Olivier Caille; Claude Rossier; Karl Perron
Journal:  J Bacteriol       Date:  2007-04-20       Impact factor: 3.490
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.