Literature DB >> 12873492

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.

David R Mole1, Imre Schlemminger, Luke A McNeill, Kirsty S Hewitson, Christopher W Pugh, Peter J Ratcliffe, Christopher J Schofield.   

Abstract

Hydroxylation of hypoxia-inducible factor, a nuclear transcription factor, is catalysed by iron and 2-oxoglutarate dependent hydroxylases. Various analogues of the 2-oxoglutarate cosubstrate were synthesised and shown to inhibit the activity of human hypoxia-inducible factor-1alpha prolyl hydroxylases in cell-free extracts.

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Year:  2003        PMID： 12873492     DOI： 10.1016/s0960-894x(03)00539-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  56 in total

Review 1.  Adenosine and hypoxia-inducible factor signaling in intestinal injury and recovery.

Authors:  Sean P Colgan; Holger K Eltzschig
Journal:  Annu Rev Physiol       Date:  2011-11-19       Impact factor: 19.318

2.  Metabolic regulation of intestinal epithelial barrier during inflammation.

Authors:  Sean P Colgan; Valerie F Curtis; Jordi M Lanis; Louise E Glover
Journal:  Tissue Barriers       Date:  2015-04-03

Review 3.  Cellular oxygen sensing in health and disease.

Authors:  David R Mole; Peter J Ratcliffe
Journal:  Pediatr Nephrol       Date:  2007-10-23       Impact factor: 3.714

4.  α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4).

Authors:  Yohannes Hagos; Gunnar Schley; Johannes Schödel; Wolfgang Krick; Gerhard Burckhardt; Carsten Willam; Birgitta C Burckhardt
Journal:  Pflugers Arch       Date:  2012-08-09       Impact factor: 3.657

5.  The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.

Authors:  Rasheduzzaman Chowdhury; Kar Kheng Yeoh; Ya-Min Tian; Lars Hillringhaus; Eleanor A Bagg; Nathan R Rose; Ivanhoe K H Leung; Xuan S Li; Esther C Y Woon; Ming Yang; Michael A McDonough; Oliver N King; Ian J Clifton; Robert J Klose; Timothy D W Claridge; Peter J Ratcliffe; Christopher J Schofield; Akane Kawamura
Journal:  EMBO Rep       Date:  2011-04-01       Impact factor: 8.807

Review 6.  Diabetic nephropathy: a disorder of oxygen metabolism?

Authors:  Toshio Miyata; Charles van Ypersele de Strihou
Journal:  Nat Rev Nephrol       Date:  2009-12-15       Impact factor: 28.314

Review 7.  Hypoxia and Mucosal Inflammation.

Authors:  Sean P Colgan; Eric L Campbell; Douglas J Kominsky
Journal:  Annu Rev Pathol       Date:  2016-05-23       Impact factor: 23.472

8.  Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy.

Authors:  Jonathan E Sears; George Hoppe; Quteba Ebrahem; Bela Anand-Apte
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-04       Impact factor: 11.205

9.  Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice.

Authors:  Malgorzata Milkiewicz; Christopher W Pugh; Stuart Egginton
Journal:  J Physiol       Date:  2004-08-19       Impact factor: 5.182

10.  Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches.

Authors:  Nathan R Rose; Esther C Y Woon; Guy L Kingham; Oliver N F King; Jasmin Mecinović; Ian J Clifton; Stanley S Ng; Jobina Talib-Hardy; Udo Oppermann; Michael A McDonough; Christopher J Schofield
Journal:  J Med Chem       Date:  2010-02-25       Impact factor: 7.446
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