Literature DB >> 12873481

Antitumor activity of unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin.

Young-Jae You1, Yong Kim, Nguyen-Hai Nam, Byung-Zun Ahn.   

Abstract

Unsaturated fatty acid esters of 4'-demethyldeoxypodophyllotoxin (DDPT) were prepared and tested for antitumor activity. The esters showed increased in vivo antitumor activity despite the lower in vitro activity than DDPT. Especially, the ester (DFE12) of all-cis-11,14-eicosadienoic acid was much better (IR, 83%) than VP-16 (IR, 60%) without loss of body weight. Unsaturated fatty acids could be evaluated to be good carrier vehicles of DDPT.

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Year:  2003        PMID： 12873481     DOI： 10.1016/s0960-894x(03)00558-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives.

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Journal:  Bioorg Med Chem       Date:  2011-10-02       Impact factor: 3.641

Review 2.  Improved biochemical strategies for targeted delivery of taxoids.

Authors:  Thota Ganesh
Journal:  Bioorg Med Chem       Date:  2007-03-18       Impact factor: 3.641

3.  Antiproliferation and cell apoptosis inducing bioactivities of constituents from Dysosma versipellis in PC3 and Bcap-37 cell lines.

Authors:  Xiaoqiang Xu; Xiuhong Gao; Linhong Jin; Pinaki S Bhadury; Kai Yuan; Deyu Hu; Baoan Song; Song Yang
Journal:  Cell Div       Date:  2011-06-15       Impact factor: 5.130

4.  (E)-N'-Arylidene-2-(4-oxoquinazolin-4(3H)-yl) acetohydrazides: Synthesis and evaluation of antitumor cytotoxicity and caspase activation activity.

Authors:  Le Cong Huan; Cao Viet Phuong; Le Cong Truc; Vo Nguyen Thanh; Hai Pham-The; Le-Thi-Thu Huong; Nguyen Thi Thuan; Eun Jae Park; A Young Ji; Jong Soon Kang; Sang-Bae Han; Phuong-Thao Tran; Nguyen-Hai Nam
Journal:  J Enzyme Inhib Med Chem       Date:  2019-12       Impact factor: 5.051
  4 in total

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