Literature DB >> 12871146

Oxidation of goat hepatic galectin-1 induces change in secondary structure.

Abhay H Pande1, Rajesh K Gupta, Krishnan Hajela.   

Abstract

Galectin-1 requires a reducing environment for its lectin activity and the carbohydrate binding function is destroyed in oxidizing condition. In this report we provide direct evidence that the oxidation of goat hepatic galectin-1 perturbs its carbohydrate recognition domain and this could be due to changes in secondary structure of goat hepatic galectin-1. Conformational changes in goat hepatic galectin-1 due to oxidation were investigated by absorption, fluorescence and circular dichroism measurements.

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Year:  2003        PMID： 12871146     DOI： 10.2174/0929866033478960

Source DB:  PubMed          Journal:  Protein Pept Lett        ISSN： 0929-8665            Impact factor:   1.890


  5 in total

1.  Structural basis of redox-dependent modulation of galectin-1 dynamics and function.

Authors:  Carlos M Guardia; Julio J Caramelo; Madia Trujillo; Santiago P Méndez-Huergo; Rafael Radi; Darío A Estrin; Gabriel A Rabinovich
Journal:  Glycobiology       Date:  2014-01-21       Impact factor: 4.313

Review 2.  Evolving mechanistic insights into galectin functions.

Authors:  Connie M Arthur; Marcelo Dias Baruffi; Richard D Cummings; Sean R Stowell
Journal:  Methods Mol Biol       Date:  2015

Review 3.  Key regulators of galectin-glycan interactions.

Authors:  Nourine A Kamili; Connie M Arthur; Christian Gerner-Smidt; Eden Tafesse; Anna Blenda; Marcelo Dias-Baruffi; Sean R Stowell
Journal:  Proteomics       Date:  2016-12       Impact factor: 3.984

4.  Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation.

Authors:  Sean R Stowell; Moonjae Cho; Christa L Feasley; Connie M Arthur; Xuezheng Song; Jennifer K Colucci; Sougata Karmakar; Padmaja Mehta; Marcelo Dias-Baruffi; Rodger P McEver; Richard D Cummings
Journal:  J Biol Chem       Date:  2008-12-22       Impact factor: 5.157

Review 5.  The Sweet-Side of Leukocytes: Galectins as Master Regulators of Neutrophil Function.

Authors:  Brian S Robinson; Connie M Arthur; Birk Evavold; Ethan Roback; Nourine A Kamili; Caleb S Stowell; Mary L Vallecillo-Zúniga; Pam M Van Ry; Marcelo Dias-Baruffi; Richard D Cummings; Sean R Stowell
Journal:  Front Immunol       Date:  2019-08-07       Impact factor: 8.786
  5 in total

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