| Literature DB >> 12870565 |
Fernanda de-Paris1, Marcia K Sant'Anna, Monica R M Vianna, Tatiana Barichello, Joao V Busnello, Flavio Kapczinski, Joao Quevedo, Ivan Izquierdo.
Abstract
The effects of gabapentin, 400 mg and 800 mg, on anxiety induced by simulated public speaking (SPS) were investigated. Thirty-two normal male volunteers (aged 17-30 years) had their anxiety and mood evaluated by self-scales [Visual Analogue Mood Scale (VAMS) and Profile of Mood State (POMS)] during the SPS procedure. Physiological measures (heart rate and blood pressure) were taken. Treatment with gabapentin at 800 mg attenuated the anxiety of subjects that had a decrease on the VAMS item calm-excite. In addition, volunteers that received gabapentin at 400 mg and 800 mg showed a decrease in the hostility score in POMS. Our results suggest, in agreement with other studies, an anxiolytic potential to gabapentin.Entities:
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Year: 2003 PMID： 12870565 DOI： 10.1177/0269881103017002006
Source DB: PubMed Journal: J Psychopharmacol ISSN： 0269-8811 Impact factor: 4.153