Literature DB >> 12869830

Differential expression of natural killer receptors on Vdelta1 gammadelta T cells in HIV-1-infected individuals.

Daniela Wesch1, Dieter Kabelitz.   

Abstract

gammadelta T cells expressing the Vdelta1 T-cell receptor are increased in HIV-1-infected individuals. Since T-cell activation is modulated by inhibitory and activating natural killer receptors (NKRs), we investigated the expression of NKRs on Vdelta1 T cells in 22 HIV-1 infected patients by 2-color flow cytometry. We observed a strongly increased expression of several NKRs on ex vivo analyzed Vdelta1 T cells from HIV+ patients. Furthermore, we show that the in vitro stimulation of CD94- Vdelta1 T cells induced strong expression of inhibitory NKR CD94/CD159A (NKG2A). Our results suggest that the increased expression of NKRs might result from chronic activation of Vdelta1 T cells in HIV-1-infected persons.

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Year:  2003        PMID： 12869830     DOI： 10.1097/00126334-200308010-00002

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  7 in total

1.  NKG2A and CD56 are coexpressed on activated TH2 but not TH1 lymphocytes.

Authors:  Robert J Freishtat; Lindsay W Mitchell; Svetlana D Ghimbovschi; Samuel B Meyers; Eric P Hoffman
Journal:  Hum Immunol       Date:  2006-03-27       Impact factor: 2.850

Review 2.  γδ T-cell responses during HIV infection and antiretroviral therapy.

Authors:  Jennifer A Juno; Emily M Eriksson
Journal:  Clin Transl Immunology       Date:  2019-07-17

Review 3.  Antiviral reactivities of gammadelta T cells.

Authors:  Fabrizio Poccia; Chiara Agrati; Federico Martini; Maria Rosaria Capobianchi; Marianne Wallace; Miroslav Malkovsky
Journal:  Microbes Infect       Date:  2005-03-03       Impact factor: 2.700

4.  Role of NKG2a/c+CD8+ T cells in pathogenic versus non-pathogenic SIV infections.

Authors:  Nicolas Huot; Philippe Rascle; Nicolas Tchitchek; Benedikt Wimmer; Caroline Passaes; Vanessa Contreras; Delphine Desjardins; Christiane Stahl-Hennig; Roger Le Grand; Asier Saez-Cirion; Beatrice Jacquelin; Michaela Müller-Trutwin
Journal:  iScience       Date:  2021-03-15

Review 5.  Human gamma delta T cells: candidates for the development of immunotherapeutic strategies.

Authors:  Susann Beetz; Lothar Marischen; Dieter Kabelitz; Daniela Wesch
Journal:  Immunol Res       Date:  2007       Impact factor: 4.505

6.  Downregulation of CD94/NKG2A inhibitory receptors on CD8+ T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts.

Authors:  Mustapha Zeddou; Souad Rahmouni; Arnaud Vandamme; Nathalie Jacobs; Frédéric Frippiat; Philippe Leonard; Nicole Schaaf-Lafontaine; Dolores Vaira; Jacques Boniver; Michel Moutschen
Journal:  Retrovirology       Date:  2007-10-10       Impact factor: 4.602

7.  Human Peripheral Blood Gamma Delta T Cells: Report on a Series of Healthy Caucasian Portuguese Adults and Comprehensive Review of the Literature.

Authors:  Sónia Fonseca; Vanessa Pereira; Catarina Lau; Maria Dos Anjos Teixeira; Marika Bini-Antunes; Margarida Lima
Journal:  Cells       Date:  2020-03-16       Impact factor: 6.600
  7 in total

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