OBJECTIVE: We recently identified a missense variant (Glu298Asp) within exon 7 of the endothelial nitric oxide synthase (eNOS) gene that is associated with severe preeclampsia in the Japanese population. Our objective was to analyze the association between the Glu298Asp eNOS gene variant and severe preeclampsia in a developing country where the incidence of preeclampsia is more frequent. METHODS: The study included 112 Bangladeshi women exhibiting severe preeclampsia and 119 control subjects. Screening for the Glu298Asp eNOS gene variant was carried out by analysis of the polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The analysis revealed that the frequencies of the Glu298Asp variant (Glu298Asp homozygotes and heterozygotes) in the preeclampsia (n = 40; 35%) and control (n = 42; 35%) groups were not significantly (p > 0.05) different. CONCLUSIONS: We conclude that the presence of the Glu298Asp eNOS gene is not a marker for the increased risk of preeclampsia in a population where the level of prenatal care is such that preeclampsia is still frequently seen. Copyright 2003 S. Karger AG, Basel
OBJECTIVE: We recently identified a missense variant (Glu298Asp) within exon 7 of the endothelial nitric oxide synthase (eNOS) gene that is associated with severe preeclampsia in the Japanese population. Our objective was to analyze the association between the Glu298AspeNOS gene variant and severe preeclampsia in a developing country where the incidence of preeclampsia is more frequent. METHODS: The study included 112 Bangladeshi women exhibiting severe preeclampsia and 119 control subjects. Screening for the Glu298AspeNOS gene variant was carried out by analysis of the polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The analysis revealed that the frequencies of the Glu298Asp variant (Glu298Asp homozygotes and heterozygotes) in the preeclampsia (n = 40; 35%) and control (n = 42; 35%) groups were not significantly (p > 0.05) different. CONCLUSIONS: We conclude that the presence of the Glu298AspeNOS gene is not a marker for the increased risk of preeclampsia in a population where the level of prenatal care is such that preeclampsia is still frequently seen. Copyright 2003 S. Karger AG, Basel
Authors: Kalliopi I Pappa; Maria Roubelakis; George Vlachos; Spyros Marinopoulos; Antonia Zissou; Nicholas P Anagnou; Aris Antsaklis Journal: J Matern Fetal Neonatal Med Date: 2010-09-14
Authors: Christina K H Yu; Juan P Casas; Makrina D Savvidou; Manpreet K Sahemey; Kypros H Nicolaides; Aroon D Hingorani Journal: BMC Pregnancy Childbirth Date: 2006-03-16 Impact factor: 3.007