Literature DB >> 12867476

A 65-kilobase pathogenicity island is unique to Philadelphia-1 strains of Legionella pneumophila.

Ann Karen C Brassinga1, Margot F Hiltz, Gary R Sisson, Michael G Morash, Nathan Hill, Elizabeth Garduno, Paul H Edelstein, Rafael A Garduno, Paul S Hoffman.   

Abstract

Nucleotide sequence analysis of an approximately 80-kb genomic region revealed an approximately 65-kb locus that bears hallmarks of a pathogenicity island. This locus includes homologues of a type IV secretion system, mobile genetic elements, and known virulence factors. Comparative studies with other Legionella pneumophila strains and serogroups indicated that this approximately 65-kb locus is unique to L. pneumophila serogroup 1 Philadelphia-1 strains.

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Year:  2003        PMID： 12867476      PMCID： PMC165780          DOI： 10.1128/JB.185.15.4630-4637.2003

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  39 in total

1.  Pan-European study on culture-proven Legionnaires' disease: distribution of Legionella pneumophila serogroups and monoclonal subgroups.

Authors:  J H Helbig; S Bernander; M Castellani Pastoris; J Etienne; V Gaia; S Lauwers; D Lindsay; P C Lück; T Marques; S Mentula; M F Peeters; C Pelaz; M Struelens; S A Uldum; G Wewalka; T G Harrison
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2002-10-18       Impact factor: 3.267

2.  Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages.

Authors:  G Segal; H A Shuman
Journal:  Infect Immun       Date:  1999-05       Impact factor: 3.441

3.  Ultrastructural analysis of differentiation in Legionella pneumophila.

Authors:  Gary Faulkner; Rafael A Garduño
Journal:  J Bacteriol       Date:  2002-12       Impact factor: 3.490

4.  Bacterial secrets of secretion: EuroConference on the biology of type IV secretion processes.

Authors:  Christian Baron; David OCallaghan; Erich Lanka
Journal:  Mol Microbiol       Date:  2002-03       Impact factor: 3.501

5.  Monoclonal antibody reactivity as a virulence marker for Legionella pneumophila serogroup 1 strains.

Authors:  E Dournon; W F Bibb; P Rajagopalan; N Desplaces; R M McKinney
Journal:  J Infect Dis       Date:  1988-03       Impact factor: 5.226

6.  Overexpresssion of a Legionella pneumophila homologue of the E. coli regulator csrA affects cell size, flagellation, and pigmentation.

Authors:  P S Fettes; V Forsbach-Birk; D Lynch; R Marre
Journal:  Int J Med Microbiol       Date:  2001-11       Impact factor: 3.473

Review 7.  Analysis of the sequence and gene products of the transfer region of the F sex factor.

Authors:  L S Frost; K Ippen-Ihler; R A Skurray
Journal:  Microbiol Rev       Date:  1994-06

8.  Relationships between a new type IV secretion system and the icm/dot virulence system of Legionella pneumophila.

Authors:  G Segal; J J Russo; H A Shuman
Journal:  Mol Microbiol       Date:  1999-11       Impact factor: 3.501

9.  Peptide methionine sulfoxide reductase (MsrA) is a virulence determinant in Mycoplasma genitalium.

Authors:  S Dhandayuthapani; M W Blaylock; C M Bebear; W G Rasmussen; J B Baseman
Journal:  J Bacteriol       Date:  2001-10       Impact factor: 3.490

Review 10.  Pathogenicity islands and the evolution of microbes.

Authors:  J Hacker; J B Kaper
Journal:  Annu Rev Microbiol       Date:  2000       Impact factor: 15.500
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  23 in total

1.  Expression of magA in Legionella pneumophila Philadelphia-1 is developmentally regulated and a marker of formation of mature intracellular forms.

Authors:  Margot F Hiltz; Gary R Sisson; Ann Karen C Brassinga; Elizabeth Garduno; Rafael A Garduno; Paul S Hoffman
Journal:  J Bacteriol       Date:  2004-05       Impact factor: 3.490

2.  Regulation of hypercompetence in Legionella pneumophila.

Authors:  Jessica A Sexton; Joseph P Vogel
Journal:  J Bacteriol       Date:  2004-06       Impact factor: 3.490

Review 3.  Molecular pathogenesis of infections caused by Legionella pneumophila.

Authors:  Hayley J Newton; Desmond K Y Ang; Ian R van Driel; Elizabeth L Hartland
Journal:  Clin Microbiol Rev       Date:  2010-04       Impact factor: 26.132

4.  Legionella anisa, a possible indicator of water contamination by Legionella pneumophila.

Authors:  Nathalie van der Mee-Marquet; Anne-Sophie Domelier; Laurence Arnault; Daniel Bloc; Patrice Laudat; Philippe Hartemann; Roland Quentin
Journal:  J Clin Microbiol       Date:  2006-01       Impact factor: 5.948

5.  Analysis of the transcriptome of Legionella pneumophila hfq mutant reveals a new mobile genetic element.

Authors:  Hana Trigui; Paulina Dudyk; Janet Sum; Howard A Shuman; Sebastien P Faucher
Journal:  Microbiology       Date:  2013-05-31       Impact factor: 2.777

6.  DsbA2 (27 kDa Com1-like protein) of Legionella pneumophila catalyses extracytoplasmic disulphide-bond formation in proteins including the Dot/Icm type IV secretion system.

Authors:  Max Jameson-Lee; Rafael A Garduño; Paul S Hoffman
Journal:  Mol Microbiol       Date:  2011-03-22       Impact factor: 3.501

Review 7.  Integrative and Conjugative Elements (ICEs): What They Do and How They Work.

Authors:  Christopher M Johnson; Alan D Grossman
Journal:  Annu Rev Genet       Date:  2015-10-14       Impact factor: 16.830

8.  The DotL protein, a member of the TraG-coupling protein family, is essential for Viability of Legionella pneumophila strain Lp02.

Authors:  Benjamin A Buscher; Gloria M Conover; Jennifer L Miller; Sinae A Vogel; Stacey N Meyers; Ralph R Isberg; Joseph P Vogel
Journal:  J Bacteriol       Date:  2005-05       Impact factor: 3.490

9.  Variable genetic element typing: a quick method for epidemiological subtyping of Legionella pneumophila.

Authors:  K Pannier; K Heuner; C Lück
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-01-30       Impact factor: 3.267

10.  Legionella pneumophila pangenome reveals strain-specific virulence factors.

Authors:  Giuseppe D'Auria; Nuria Jiménez-Hernández; Francesc Peris-Bondia; Andrés Moya; Amparo Latorre
Journal:  BMC Genomics       Date:  2010-03-17       Impact factor: 3.969
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