Literature DB >> 12867474

Biochemical function of msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv: biosynthesis of monomethyl branched unsaturated fatty acids.

Vinod S Dubey1, Tatiana D Sirakova, Michael H Cynamon, Pappachan E Kolattukudy.   

Abstract

We show that the disruption of one of the mycocerosic acid synthase (mas)-like genes, msl5 (pks8 plus pks17) in Mycobacterium tuberculosis H37Rv generates a mutant incapable of producing monomethyl branched unsaturated C(16) to C(20) fatty acids that are minor constituents of acyltrehaloses and sulfolipids. The msl5 mutation did not cause any significant change in the acyl lipid composition and also did not affect growth in culture, in mouse alveolar macrophage cell line MH-S, or in the murine lung.

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Year:  2003        PMID： 12867474      PMCID： PMC165776          DOI： 10.1128/JB.185.15.4620-4625.2003

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  25 in total

1.  The Mycobacterium tuberculosis pks2 gene encodes the synthase for the hepta- and octamethyl-branched fatty acids required for sulfolipid synthesis.

Authors:  T D Sirakova; A K Thirumala; V S Dubey; H Sprecher; P E Kolattukudy
Journal:  J Biol Chem       Date:  2001-02-23       Impact factor: 5.157

2.  Iron-cofactored superoxide dismutase inhibits host responses to Mycobacterium tuberculosis.

Authors:  K M Edwards; M H Cynamon; R K Voladri; C C Hager; M S DeStefano; K T Tham; D L Lakey; M R Bochan; D S Kernodle
Journal:  Am J Respir Crit Care Med       Date:  2001-12-15       Impact factor: 21.405

3.  Massive gene decay in the leprosy bacillus.

Authors:  S T Cole; K Eiglmeier; J Parkhill; K D James; N R Thomson; P R Wheeler; N Honoré; T Garnier; C Churcher; D Harris; K Mungall; D Basham; D Brown; T Chillingworth; R Connor; R M Davies; K Devlin; S Duthoy; T Feltwell; A Fraser; N Hamlin; S Holroyd; T Hornsby; K Jagels; C Lacroix; J Maclean; S Moule; L Murphy; K Oliver; M A Quail; M A Rajandream; K M Rutherford; S Rutter; K Seeger; S Simon; M Simmonds; J Skelton; R Squares; S Squares; K Stevens; K Taylor; S Whitehead; J R Woodward; B G Barrell
Journal:  Nature       Date:  2001-02-22       Impact factor: 49.962

4.  Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.

Authors:  Laurent Kremer; Lynn G Dover; Séverine Carrère; K Madhavan Nampoothiri; Sarah Lesjean; Alistair K Brown; Patrick J Brennan; David E Minnikin; Camille Locht; Gurdyal S Besra
Journal:  Biochem J       Date:  2002-06-01       Impact factor: 3.857

5.  Attenuation of Mycobacterium tuberculosis by disruption of a mas-like gene or a chalcone synthase-like gene, which causes deficiency in dimycocerosyl phthiocerol synthesis.

Authors:  Tatiana D Sirakova; Vinod S Dubey; Michael H Cynamon; Pappachan E Kolattukudy
Journal:  J Bacteriol       Date:  2003-05       Impact factor: 3.490

6.  Disruption of msl3 abolishes the synthesis of mycolipanoic and mycolipenic acids required for polyacyltrehalose synthesis in Mycobacterium tuberculosis H37Rv and causes cell aggregation.

Authors:  Vinod S Dubey; Tatiana D Sirakova; P E Kolattukudy
Journal:  Mol Microbiol       Date:  2002-09       Impact factor: 3.501

7.  Virulence attenuation of two Mas-like polyketide synthase mutants of Mycobacterium tuberculosis.

Authors:  Cécile Rousseau; Tatiana D Sirakova; Vinod S Dubey; Yann Bordat; Pappachan E Kolattukudy; Brigitte Gicquel; Mary Jackson
Journal:  Microbiology       Date:  2003-07       Impact factor: 2.777

8.  Role of the pks15/1 gene in the biosynthesis of phenolglycolipids in the Mycobacterium tuberculosis complex. Evidence that all strains synthesize glycosylated p-hydroxybenzoic methyl esters and that strains devoid of phenolglycolipids harbor a frameshift mutation in the pks15/1 gene.

Authors:  Patricia Constant; Esther Perez; Wladimir Malaga; Marie-Antoinette Lanéelle; Olivier Saurel; Mamadou Daffé; Christophe Guilhot
Journal:  J Biol Chem       Date:  2002-07-22       Impact factor: 5.157

9.  Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis.

Authors:  Stoyan Bardarov; Svetoslav Bardarov; Martin S Pavelka; Vasan Sambandamurthy; Michelle Larsen; JoAnn Tufariello; John Chan; Graham Hatfull; William R Jacobs
Journal:  Microbiology       Date:  2002-10       Impact factor: 2.777

10.  The largest open reading frame (pks12) in the Mycobacterium tuberculosis genome is involved in pathogenesis and dimycocerosyl phthiocerol synthesis.

Authors:  Tatiana D Sirakova; Vinod S Dubey; Hwa-Jung Kim; Michael H Cynamon; Pappachan E Kolattukudy
Journal:  Infect Immun       Date:  2003-07       Impact factor: 3.441
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  13 in total

Review 1.  Microbial type I fatty acid synthases (FAS): major players in a network of cellular FAS systems.

Authors:  Eckhart Schweizer; Jörg Hofmann
Journal:  Microbiol Mol Biol Rev       Date:  2004-09       Impact factor: 11.056

2.  Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression.

Authors:  Elisa Dainese; Sébastien Rodrigue; Giovanni Delogu; Roberta Provvedi; Liette Laflamme; Ryszard Brzezinski; Giovanni Fadda; Issar Smith; Luc Gaudreau; Giorgio Palù; Riccardo Manganelli
Journal:  Infect Immun       Date:  2006-04       Impact factor: 3.441

Review 3.  The Mycobacterium tuberculosis cytochrome P450 system.

Authors:  Hugues Ouellet; Jonathan B Johnston; Paul R Ortiz de Montellano
Journal:  Arch Biochem Biophys       Date:  2009-07-25       Impact factor: 4.013

4.  Defining mycobacteria: Shared and specific genome features for different lifestyles.

Authors:  Varalakshmi D Vissa; Rama Murthy Sakamuri; Wei Li; Patrick J Brennan
Journal:  Indian J Microbiol       Date:  2009-02-05       Impact factor: 2.461

5.  Genetics of Capsular Polysaccharides and Cell Envelope (Glyco)lipids.

Authors:  Mamadou Daffé; Dean C Crick; Mary Jackson
Journal:  Microbiol Spectr       Date:  2014

6.  Mycobacterial polyketide-associated proteins are acyltransferases: proof of principle with Mycobacterium tuberculosis PapA5.

Authors:  Kenolisa C Onwueme; Julian A Ferreras; John Buglino; Christopher D Lima; Luis E N Quadri
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-18       Impact factor: 11.205

7.  Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture.

Authors:  Jaiyanth Daniel; Chirajyoti Deb; Vinod S Dubey; Tatiana D Sirakova; Bassam Abomoelak; Hector R Morbidoni; Pappachan E Kolattukudy
Journal:  J Bacteriol       Date:  2004-08       Impact factor: 3.490

8.  A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra.

Authors:  Marie-Laure Chesne-Seck; Nathalie Barilone; Frédéric Boudou; Jesús Gonzalo Asensio; Pappachan E Kolattukudy; Carlos Martín; Stewart T Cole; Brigitte Gicquel; Deshmukh N Gopaul; Mary Jackson
Journal:  J Bacteriol       Date:  2007-12-07       Impact factor: 3.490

Review 9.  The cell envelope glycoconjugates of Mycobacterium tuberculosis.

Authors:  Shiva Kumar Angala; Juan Manuel Belardinelli; Emilie Huc-Claustre; William H Wheat; Mary Jackson
Journal:  Crit Rev Biochem Mol Biol       Date:  2014-06-10       Impact factor: 8.250

10.  Mycobacterium tuberculosis acyl carrier protein synthase adopts two different pH-dependent structural conformations.

Authors:  Kuppan Gokulan; Anup Aggarwal; Lance Shipman; Gurdyal S Besra; James C Sacchettini
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2011-06-11
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