Literature DB >> 12867100

Fluconazole in combination with flucytosine in the treatment of fluconazole-resistant Candida infections.

Corrado Girmenia1, Mario Venditti, Pietro Martino.   

Abstract

Two patients with renal failure and fluconazole resistant but flucytosine susceptible Candida deep infection were successfully treated with the combination of the two drugs. In vitro susceptibility, determined by microdilution and time-kill methods, and fungostatic activity of the serum showed an additive interaction of fluconazole and flucytosine. In the event of infections by Candida isolates resistant to fluconazole but susceptible to 5-fluorocytosine, the combination of these drugs may be a possible therapeutic choice.

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Year:  2003        PMID： 12867100     DOI： 10.1016/s0732-8893(03)00064-6

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  7 in total

1.  Successful treatment of Candida glabrata peritonitis with fluconazole plus flucytosine in a premature infant following in vitro fertilization.

Authors:  A M Freydiere; M A Piens; J M Andre; G Putet; S Picot
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2005-10       Impact factor: 3.267

2.  Multilaboratory testing of two-drug combinations of antifungals against Candida albicans, Candida glabrata, and Candida parapsilosis.

Authors:  Vishnu Chaturvedi; Rama Ramani; David Andes; Daniel J Diekema; Michael A Pfaller; Mahmoud A Ghannoum; Cindy Knapp; Shawn R Lockhart; Luis Ostrosky-Zeichner; Thomas J Walsh; Karen Marchillo; Shawn Messer; Amanda R Welshenbaugh; Cara Bastulli; Noreen Iqbal; Victor L Paetznick; Jose Rodriguez; Tin Sein
Journal:  Antimicrob Agents Chemother       Date:  2011-01-31       Impact factor: 5.191

3.  Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against Candida albicans.

Authors:  Aaron D Mood; Ilandari Dewage Udara Anulal Premachandra; Stanley Hiew; Fuqiang Wang; Kevin A Scott; Nathan J Oldenhuis; Haoping Liu; David L Van Vranken
Journal:  ACS Med Chem Lett       Date:  2017-01-11       Impact factor: 4.345

Review 4.  Combination treatment of invasive fungal infections.

Authors:  Pranab K Mukherjee; Daniel J Sheehan; Christopher A Hitchcock; Mahmoud A Ghannoum
Journal:  Clin Microbiol Rev       Date:  2005-01       Impact factor: 26.132

Review 5.  Invasive candidiasis in pediatric intensive care patients: epidemiology, risk factors, management, and outcome.

Authors:  Joanna Filioti; Kleomenis Spiroglou; Emmanuel Roilides
Journal:  Intensive Care Med       Date:  2007-05-15       Impact factor: 17.440

Review 6.  Techniques for the Assessment of In Vitro and In Vivo Antifungal Combinations.

Authors:  Anne-Laure Bidaud; Patrick Schwarz; Guillaume Herbreteau; Eric Dannaoui
Journal:  J Fungi (Basel)       Date:  2021-02-04

7.  Combination of Six Individual Derivatives of the Pom-1 Antibiofilm Peptide Doubles Their Efficacy against Invasive and Multi-Resistant Clinical Isolates of the Pathogenic Yeast Candida albicans.

Authors:  Michelle Häring; Valerie Amann; Ann-Kathrin Kissmann; Tilmann Herberger; Christopher Synatschke; Nicole Kirsch-Pietz; Julio A Perez-Erviti; Anselmo J Otero-Gonzalez; Fidel Morales-Vicente; Jakob Andersson; Tanja Weil; Steffen Stenger; Armando Rodríguez; Ludger Ständker; Frank Rosenau
Journal:  Pharmaceutics       Date:  2022-06-24       Impact factor: 6.525
  7 in total

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