Literature DB >> 12866832

Regulated assembly of the mitotic spindle: a perspective from two ends.

Lynne Cassimeris1, Robert V Skibbens.   

Abstract

Chromosome segregration and cell division requires the regulated assembly of the mitotic spindle apparatus. This mitotic spindle is composed of condensed chromosomes attached to a dynamic array of microtubules. The microtubule array is nucleated by centrosomes and organized by associated structural and motor proteins. Mechanical linkages between sister chromatids and microtubules are critical for spindle assembly and chromosome segregation. Defects in either chromosome or centrosome segregation can lead to aneuploidy and are correlated with cancer progression. In this review, we discuss current models of how centrosomes and chromosomes organize the spindle for their equal distribution to each daughter cell.

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Year:  2003        PMID： 12866832

Source DB:  PubMed          Journal:  Curr Issues Mol Biol        ISSN： 1467-3037            Impact factor:   2.081


  9 in total

1.  Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells.

Authors:  Adam I Marcus; Ulf Peters; Shala L Thomas; Sarah Garrett; Amelia Zelnak; Tarun M Kapoor; Paraskevi Giannakakou
Journal:  J Biol Chem       Date:  2005-01-13       Impact factor: 5.157

2.  Identifying Host Factors Associated with DNA Replicated During Virus Infection.

Authors:  Emigdio D Reyes; Katarzyna Kulej; Neha J Pancholi; Lisa N Akhtar; Daphne C Avgousti; Eui Tae Kim; Daniel K Bricker; Lynn A Spruce; Sarah A Koniski; Steven H Seeholzer; Stuart N Isaacs; Benjamin A Garcia; Matthew D Weitzman
Journal:  Mol Cell Proteomics       Date:  2017-10-02       Impact factor: 5.911

3.  The Xenopus TACC homologue, maskin, functions in mitotic spindle assembly.

Authors:  Lori L O'Brien; Alison J Albee; Lingling Liu; Wei Tao; Pawel Dobrzyn; Sofia B Lizarraga; Christiane Wiese
Journal:  Mol Biol Cell       Date:  2005-03-23       Impact factor: 4.138

4.  Analysis of gene expression profiles of hepatocellular carcinomas with regard to 18F-fluorodeoxyglucose uptake pattern on positron emission tomography.

Authors:  Jong Doo Lee; Mijin Yun; Jae Myun Lee; Youjeong Choi; Youn-Hee Choi; Ji Su Kim; Se Jong Kim; Kyung Sik Kim; Woo Ick Yang; Young Nyun Park; Kwang-Hyub Han; Woo Jung Lee; Naechun Yoo; Sang Moo Lim; Jeon Han Park
Journal:  Eur J Nucl Med Mol Imaging       Date:  2004-07-28       Impact factor: 9.236

5.  Human EFO1p exhibits acetyltransferase activity and is a unique combination of linker histone and Ctf7p/Eco1p chromatid cohesion establishment domains.

Authors:  Aaron M Bellows; Margaret A Kenna; Lynne Cassimeris; Robert V Skibbens
Journal:  Nucleic Acids Res       Date:  2003-11-01       Impact factor: 16.971

Review 6.  Splitting the cell, building the organism: Mechanisms of cell division in metazoan embryos.

Authors:  Megha Kumar; Kumari Pushpa; Sivaram V S Mylavarapu
Journal:  IUBMB Life       Date:  2015-07-14       Impact factor: 3.885

7.  CaM kinase II initiates meiotic spindle depolymerization independently of APC/C activation.

Authors:  Simone Reber; Sabine Over; Iva Kronja; Oliver J Gruss
Journal:  J Cell Biol       Date:  2008-12-08       Impact factor: 10.539

8.  Kinesin-14 Pkl1 targets γ-tubulin for release from the γ-tubulin ring complex (γ-TuRC) ‬‬‬‬‬‬‬.

Authors:  Zachary T Olmsted; Timothy D Riehlman; Carmen N Branca; Andrew G Colliver; Leilani O Cruz; Janet L Paluh
Journal:  Cell Cycle       Date:  2013-02-06       Impact factor: 4.534

9.  The Prp19 complex directly functions in mitotic spindle assembly.

Authors:  Jennifer C Hofmann; Justus Tegha-Dunghu; Stefanie Dräger; Cindy L Will; Reinhard Lührmann; Oliver J Gruss
Journal:  PLoS One       Date:  2013-09-19       Impact factor: 3.240
  9 in total

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