Paolo Campi1, Werner J Pichler. 1. Allergy Clinic, Nuovo Ospedale San Giovanni di Dio, Florence, Italy. allergy@asf.toscana.it
Abstract
PURPOSE OF REVIEW: Quinolones are potent antibacterial agents that can cause drug hypersensitivity reactions affecting different organs. A better understanding of the underlying mechanism and the level of crossreactivity within different quinolones is needed to handle and prevent these diseases. RECENT FINDINGS: The adverse side-effects caused by quinolones are the result of different immunological mechanisms and cause quite different diseases. The development of an assay detecting quinolone-specific IgE revealed specific antibodies in more than 50% of patients with immediate-type reactions, and the majority of sera also reacted with related compounds. In maculopapular drug exanthemas caused by ciprofloxacin, specific T cells could be detected and cloned. They reacted with ciprofloxacin directly, and crossreactivity to related compounds was detected in approximately 50% of the clones. SUMMARY: Quinolones can cause drug hypersensitivity reactions by different immunological mechanisms. In-vitro analysis suggests that crossreactivity is common.
PURPOSE OF REVIEW: Quinolones are potent antibacterial agents that can cause drug hypersensitivity reactions affecting different organs. A better understanding of the underlying mechanism and the level of crossreactivity within different quinolones is needed to handle and prevent these diseases. RECENT FINDINGS: The adverse side-effects caused by quinolones are the result of different immunological mechanisms and cause quite different diseases. The development of an assay detecting quinolone-specific IgE revealed specific antibodies in more than 50% of patients with immediate-type reactions, and the majority of sera also reacted with related compounds. In maculopapular drug exanthemas caused by ciprofloxacin, specific T cells could be detected and cloned. They reacted with ciprofloxacin directly, and crossreactivity to related compounds was detected in approximately 50% of the clones. SUMMARY:Quinolones can cause drug hypersensitivity reactions by different immunological mechanisms. In-vitro analysis suggests that crossreactivity is common.
Authors: Bernhardt Sachs; Stefan Riegel; Jörg Seebeck; Rainer Beier; Dagmar Schichler; Antina Barger; Hans F Merk; Stephan Erdmann Journal: Drug Saf Date: 2006 Impact factor: 5.606
Authors: Catherine B Johannes; Najat Ziyadeh; John D Seeger; Ed Tucker; Christoph Reiter; Gerald Faich Journal: Drug Saf Date: 2007 Impact factor: 5.606