BACKGROUND: The risk of intracerebral hemorrhage in systemic thrombolysis for acute ischemic stroke after acetylsalicylic acid (ASA) pretreatment or with subsequent heparin is controversially discussed. METHODS: 300 consecutive stroke patients were treated with recombinant tissue-type plasminogen activator (rt-PA) in a prospective open study (92 pretreated with ASA, 202 ASA nonusers) with 3 months of follow-up. After thrombolysis, 122 patients received low-dose, 153 patients high-dose heparin. RESULTS: Logistic regression analysis showed no relationship of hemorrhagic complications within the first 48 h to ASA pretreatment (p = 0.15), or heparin application (p = 0.38), but dependency on stroke severity (NIHSS) at baseline (p = 0.01). CONCLUSION: ASA pretreatment does not increase the risk of symptomatic bleeding after systemic thrombolysis with rt-PA, even if thrombolysis is followed by anticoagulation. Copyright 2003 S. Karger AG, Basel
BACKGROUND: The risk of intracerebral hemorrhage in systemic thrombolysis for acute ischemic stroke after acetylsalicylic acid (ASA) pretreatment or with subsequent heparin is controversially discussed. METHODS: 300 consecutive strokepatients were treated with recombinant tissue-type plasminogen activator (rt-PA) in a prospective open study (92 pretreated with ASA, 202 ASA nonusers) with 3 months of follow-up. After thrombolysis, 122 patients received low-dose, 153 patients high-dose heparin. RESULTS: Logistic regression analysis showed no relationship of hemorrhagic complications within the first 48 h to ASA pretreatment (p = 0.15), or heparin application (p = 0.38), but dependency on stroke severity (NIHSS) at baseline (p = 0.01). CONCLUSION:ASA pretreatment does not increase the risk of symptomatic bleeding after systemic thrombolysis with rt-PA, even if thrombolysis is followed by anticoagulation. Copyright 2003 S. Karger AG, Basel
Authors: Brett A Eyford; Chaahat S B Singh; Thomas Abraham; Lonna Munro; Kyung Bok Choi; Tracy Hill; Rhonda Hildebrandt; Ian Welch; Timothy Z Vitalis; Reinhard Gabathuler; Jacob A Gordon; Hans Adomat; Emma S T Guns; Chieh-Ju Lu; Cheryl G Pfeifer; Mei Mei Tian; Wilfred A Jefferies Journal: Front Mol Biosci Date: 2021-03-26