Literature DB >> 12862421

High transfection efficiency of poly(4-vinylimidazole) as a new gene carrier.

Jong-Eun Ihm1, Ki-Ok Han, In-Kwon Han, Kwang-Duk Ahn, Dong-Keun Han, Chong-Su Cho.   

Abstract

Poly(4-vinylimidazole) (P4V) was obtained by free radical polymerization of 4-vinylimidazole (4V) prepared by decarboxylation of urocanic acid. P4V formed a complex with DNA that exhibited higher transfection effiency on Hela cells than polyethylenimine (PEI), through the proton sponge mechanism of the imidazole groups in the side chain of the P4V, and low cell toxicity.

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Year:  2003        PMID： 12862421     DOI： 10.1021/bc025611q

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  4 in total

1.  The development and mechanism studies of cationic chitosan-modified biodegradable PLGA nanoparticles for efficient siRNA drug delivery.

Authors:  Xudong Yuan; Bruhal A Shah; Naimesh K Kotadia; Jian Li; Hua Gu; Zhiqian Wu
Journal:  Pharm Res       Date:  2010-03-23       Impact factor: 4.200

2.  Coiled coil exposure and histidine tags drive function of an intracellular protein drug carrier.

Authors:  Anshul Dhankher; Wei Lv; William T Studstill; Julie A Champion
Journal:  J Control Release       Date:  2021-09-24       Impact factor: 9.776

3.  Screening for Methylated Poly(l-histidine) with Various Dimethylimidazolium/Methylimidazole/Imidazole Contents as DNA Carrier.

Authors:  Shoichiro Asayama; Takao Kumagai; Hiroyoshi Kawakami
Journal:  Pharmaceutics       Date:  2015-08-25       Impact factor: 6.321

4.  Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy.

Authors:  Gayathri Kandasamy; Elena N Danilovtseva; Vadim V Annenkov; Uma Maheswari Krishnan
Journal:  Beilstein J Nanotechnol       Date:  2020-02-17       Impact factor: 3.649
  4 in total

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