BACKGROUND: Duodenogastroesophageal reflux is common after total or partial gastrectomy. No data are available on the effect of duodenal reflux on the larynx. HYPOTHESIS: Premalignant or malignant changes occur more frequently among subjects with gastric surgery. DESIGN: Historical cohort study. SETTING: Outpatient setting for upper endoscopy. PATIENTS: Ninety-three subjects who had undergone gastric resection at least 5 years previously, and 93 matched dyspeptic individuals who did not undergo gastric surgery. INTERVENTION: Clinical histories of all patients were obtained and recorded. All subjects underwent an otolaryngologic evaluation. RESULTS: Of 93 patients with gastric resection, 7 patients had current or previous laryngeal malignancies or current precancerous mucosal changes. In the control group, 1 subject had a leukoplakia on the vocal cord. The adjusted odds ratio (having included sex, age, and alcohol [yes or no] and smoking [yes or no] history in the regression model) was 9.88 (95% confidence interval, 1.01-97.31; likelihood ratio chi2 = 28.77; P<.001). Furthermore, there was a significant increased prevalence of benign laryngeal lesions in patients with gastric resection vs the control group. CONCLUSIONS: The risk of developing laryngeal malignancies is higher for patients with gastric resection. A periodic otolaryngologic evaluation in subjects with gastric surgery may contribute to early diagnosis of laryngeal disorders.
BACKGROUND: Duodenogastroesophageal reflux is common after total or partial gastrectomy. No data are available on the effect of duodenal reflux on the larynx. HYPOTHESIS: Premalignant or malignant changes occur more frequently among subjects with gastric surgery. DESIGN: Historical cohort study. SETTING:Outpatient setting for upper endoscopy. PATIENTS: Ninety-three subjects who had undergone gastric resection at least 5 years previously, and 93 matched dyspeptic individuals who did not undergo gastric surgery. INTERVENTION: Clinical histories of all patients were obtained and recorded. All subjects underwent an otolaryngologic evaluation. RESULTS: Of 93 patients with gastric resection, 7 patients had current or previous laryngeal malignancies or current precancerous mucosal changes. In the control group, 1 subject had a leukoplakia on the vocal cord. The adjusted odds ratio (having included sex, age, and alcohol [yes or no] and smoking [yes or no] history in the regression model) was 9.88 (95% confidence interval, 1.01-97.31; likelihood ratio chi2 = 28.77; P<.001). Furthermore, there was a significant increased prevalence of benign laryngeal lesions in patients with gastric resection vs the control group. CONCLUSIONS: The risk of developing laryngeal malignancies is higher for patients with gastric resection. A periodic otolaryngologic evaluation in subjects with gastric surgery may contribute to early diagnosis of laryngeal disorders.
Authors: Michael B Cook; Sanford M Dawsey; Lena Diaw; Martin J Blaser; Guillermo I Perez-Perez; Christian C Abnet; Philip R Taylor; Demetrius Albanes; Jarmo Virtamo; Farin Kamangar Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-07-20 Impact factor: 4.254
Authors: Eugenio De Corso; Silvia Baroni; Stefania Agostino; Giovanni Cammarota; Giovanni Mascagna; Alice Mannocci; Mario Rigante; Jacopo Galli Journal: Ann Surg Date: 2007-06 Impact factor: 12.969
Authors: Nikki Johnston; Justin C Yan; Craig R Hoekzema; Tina L Samuels; Gary D Stoner; Joel H Blumin; Jonathan M Bock Journal: Laryngoscope Date: 2012-05-08 Impact factor: 3.325