Literature DB >> 12860400

Adaptive evolution in the snake venom Kunitz/BPTI protein family.

Vera Zupunski1, Dusan Kordis, Franc Gubensek.   

Abstract

Snake venoms are rich sources of serine proteinase inhibitors that are members of the Kunitz/BPTI (bovine pancreatic trypsin inhibitor) family. However, only a few of their gene sequences have been determined from snakes. We therefore cloned the cDNAs for the trypsin and chymotrypsin inhibitors from a Vipera ammodytes venom gland cDNA library. Phylogenetic analysis of these and other snake Kunitz/BPTI homologs shows the presence of three clusters, where sequences cluster by functional role. Analysis of the nucleotide sequences from the snake Kunitz/BPTI family shows that positive Darwinian selection was operating on the highly conserved BPTI fold, indicating that this family evolved by gene duplication and rapid diversification.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 12860400     DOI： 10.1016/s0014-5793(03)00693-8

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  36 in total

1.  Molecular characterization of Ancylostoma ceylanicum Kunitz-type serine protease inhibitor: evidence for a role in hookworm-associated growth delay.

Authors:  Daniel Chu; Richard D Bungiro; Maureen Ibanez; Lisa M Harrison; Eva Campodonico; Brian F Jones; Juliusz Mieszczanek; Petr Kuzmic; Michael Cappello
Journal:  Infect Immun       Date:  2004-04       Impact factor: 3.441

2.  Proteomics and deep sequencing comparison of seasonally active venom glands in the platypus reveals novel venom peptides and distinct expression profiles.

Authors:  Emily S W Wong; David Morgenstern; Ehtesham Mofiz; Sara Gombert; Katrina M Morris; Peter Temple-Smith; Marilyn B Renfree; Camilla M Whittington; Glenn F King; Wesley C Warren; Anthony T Papenfuss; Katherine Belov
Journal:  Mol Cell Proteomics       Date:  2012-08-16       Impact factor: 5.911

3.  A limited role for gene duplications in the evolution of platypus venom.

Authors:  Emily S W Wong; Anthony T Papenfuss; Camilla M Whittington; Wesley C Warren; Katherine Belov
Journal:  Mol Biol Evol       Date:  2011-08-03       Impact factor: 16.240

4.  Suppression of ADAM17-mediated Lyn/Akt pathways induces apoptosis of human leukemia U937 cells: Bungarus multicinctus protease inhibitor-like protein-1 uncovers the cytotoxic mechanism.

Authors:  Wen-Hsin Liu; Long-Sen Chang
Journal:  J Biol Chem       Date:  2010-08-02       Impact factor: 5.157

5.  Identification and anticoagulant activity of a novel Kunitz-type protein HA11 from the salivary gland of the tick Hyalomma asiaticum.

Authors:  Houshuang Zhang; Ruiqiong Qiao; Haiyan Gong; Jie Cao; Yongzhi Zhou; Jinlin Zhou
Journal:  Exp Appl Acarol       Date:  2017-01-13       Impact factor: 2.132

6.  Role of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins.

Authors:  Robin Doley; Stephen P Mackessy; R Manjunatha Kini
Journal:  BMC Evol Biol       Date:  2009-06-30       Impact factor: 3.260

7.  Novel venom gene discovery in the platypus.

Authors:  Camilla M Whittington; Anthony T Papenfuss; Devin P Locke; Elaine R Mardis; Richard K Wilson; Sahar Abubucker; Makedonka Mitreva; Emily S W Wong; Arthur L Hsu; Philip W Kuchel; Katherine Belov; Wesley C Warren
Journal:  Genome Biol       Date:  2010-09-29       Impact factor: 13.583

8.  Variability and action mechanism of a family of anticomplement proteins in Ixodes ricinus.

Authors:  Bernard Couvreur; Jérôme Beaufays; Cédric Charon; Kathia Lahaye; François Gensale; Valérie Denis; Benoît Charloteaux; Yves Decrem; Pierre-Paul Prévôt; Michel Brossard; Luc Vanhamme; Edmond Godfroid
Journal:  PLoS One       Date:  2008-01-02       Impact factor: 3.240

9.  Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins.

Authors:  Ivo M B Francischetti; Van My-Pham; Jim Harrison; Mark K Garfield; José M C Ribeiro
Journal:  Gene       Date:  2004-08-04       Impact factor: 3.688

10.  Comparative venom gland transcriptome surveys of the saw-scaled vipers (Viperidae: Echis) reveal substantial intra-family gene diversity and novel venom transcripts.

Authors:  Nicholas R Casewell; Robert A Harrison; Wolfgang Wüster; Simon C Wagstaff
Journal:  BMC Genomics       Date:  2009-11-30       Impact factor: 3.969
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.