OBJECTIVES: To compute the synchronization likelihood of multichannel electroencephalogram (EEG) data in Alzheimer (AD) patients, subjects with mild cognitive impairment (MCI) and subjects with subjective memory complaints (SC). MATERIAL AND METHODS: EEGs (200 Hz sample frequency; 21 channels; average reference) were recorded in 10 AD patients (two males; age 76.2; SD 9.36; range 59-86), 17 subjects with MCI (eight males; age 77.41; SD 6.25; range 62-88) and 20 subjects with SCI (11 males; age 68.9; SD 12.96; range: 51-89). The synchronization likelihood, a novel type of coherence measure, was computed, comparing each channel with all other channels, for the 2-6, 6-10, 10-14, 14-18, 18-22 and 22-50 Hz band. RESULTS: The synchronization likelihood was significantly decreased in the 14-18 and 18-22 Hz band in AD patients compared with both MCI subjects and healthy controls. Lower beta band synchronization correlated with lower Mini-Mental state examination (MMSE) scores. CONCLUSION: Loss of beta band synchronization occurs early in mildly affected AD patients and correlates with cognitive impairment.
OBJECTIVES: To compute the synchronization likelihood of multichannel electroencephalogram (EEG) data in Alzheimer (AD) patients, subjects with mild cognitive impairment (MCI) and subjects with subjective memory complaints (SC). MATERIAL AND METHODS: EEGs (200 Hz sample frequency; 21 channels; average reference) were recorded in 10 ADpatients (two males; age 76.2; SD 9.36; range 59-86), 17 subjects with MCI (eight males; age 77.41; SD 6.25; range 62-88) and 20 subjects with SCI (11 males; age 68.9; SD 12.96; range: 51-89). The synchronization likelihood, a novel type of coherence measure, was computed, comparing each channel with all other channels, for the 2-6, 6-10, 10-14, 14-18, 18-22 and 22-50 Hz band. RESULTS: The synchronization likelihood was significantly decreased in the 14-18 and 18-22 Hz band in ADpatients compared with both MCI subjects and healthy controls. Lower beta band synchronization correlated with lower Mini-Mental state examination (MMSE) scores. CONCLUSION: Loss of beta band synchronization occurs early in mildly affected ADpatients and correlates with cognitive impairment.
Authors: Ingeborg Bosma; Linda Douw; Fabrice Bartolomei; Jan J Heimans; Bob W van Dijk; Tjeerd J Postma; Cornelis J Stam; Jaap C Reijneveld; Martin Klein Journal: Neuro Oncol Date: 2008-07-23 Impact factor: 12.300
Authors: María Eugenia López; Pilar Garcés; Pablo Cuesta; Nazareth P Castellanos; Sara Aurtenetxe; Ricardo Bajo; Alberto Marcos; Mercedes Montenegro; Raquel Yubero; Francisco del Pozo; Miguel Sancho; Fernando Maestú Journal: Age (Dordr) Date: 2014-06