OBJECTIVES: Mild cognitive impairment is associated with an increased risk of developing dementia. However, there is no consensus on diagnostic criteria and different concepts have rarely been evaluated in population-based samples. This paper compares the prevalences and predictive validities for different concepts in a population-based study. The aim was to identify a concept with the best relation of sensitivity and specificity in the prediction of dementia. MATERIAL AND METHODS: A community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing in a three-wave longitudinal study. RESULTS: Prevalence rates ranged from 3 to 36% according to the concept applied. Conversion rates to dementia over 2.6 years ranged from 23 to 47%. In addition, receiver operating characteristic curves indicated that all but one concept for mild cognitive impairment could predict dementia. CONCLUSION: Mild cognitive impairment is very frequent in older people. Prevalences and predictive validities are highly dependent on the diagnostic criteria applied.
OBJECTIVES: Mild cognitive impairment is associated with an increased risk of developing dementia. However, there is no consensus on diagnostic criteria and different concepts have rarely been evaluated in population-based samples. This paper compares the prevalences and predictive validities for different concepts in a population-based study. The aim was to identify a concept with the best relation of sensitivity and specificity in the prediction of dementia. MATERIAL AND METHODS: A community sample of 1045 dementia-free individuals aged 75 years and over was examined by neuropsychological testing in a three-wave longitudinal study. RESULTS: Prevalence rates ranged from 3 to 36% according to the concept applied. Conversion rates to dementia over 2.6 years ranged from 23 to 47%. In addition, receiver operating characteristic curves indicated that all but one concept for mild cognitive impairment could predict dementia. CONCLUSION: Mild cognitive impairment is very frequent in older people. Prevalences and predictive validities are highly dependent on the diagnostic criteria applied.
Authors: Blossom C M Stephan; Fiona E Matthews; Brandy Ma; Graciela Muniz; Sally Hunter; Daniel Davis; Ian G McKeith; Gill Foster; Paul G Ince; Carol Brayne Journal: J Alzheimers Dis Date: 2012 Impact factor: 4.472
Authors: Ana Luisa Sosa; Emiliano Albanese; Blossom C M Stephan; Michael Dewey; Daisy Acosta; Cleusa P Ferri; Mariella Guerra; Yueqin Huang; K S Jacob; Ivonne Z Jiménez-Velázquez; Juan J Llibre Rodriguez; Aquiles Salas; Joseph Williams; Isaac Acosta; Maribella González-Viruet; Milagros A Guerra Hernandez; Li Shuran; Martin J Prince; Robert Stewart Journal: PLoS Med Date: 2012-02-07 Impact factor: 11.069