PURPOSE: To investigate the presence of human papillomavirus (HPV) DNA in tumour tissue from patients with unilateral retinoblastoma. METHODS: Samples of paraffin-embedded tumour tissue from 43 children with unilateral retinoblastoma were collected to investigate the presence of HPV DNA using polymerase chain reaction (PCR) and dot blot hybridization. RESULTS: Oncogenic HPV DNA types 16 and 35 were detected in 12 (27.9%) of 43 tumour specimens. A higher frequency of differentiated tumours (63.3%) was observed among the HPV-positive tumours. CONCLUSIONS: Future studies are necessary to demonstrate an association between HPV and sporadic retinoblastoma.
PURPOSE: To investigate the presence of human papillomavirus (HPV) DNA in tumour tissue from patients with unilateral retinoblastoma. METHODS: Samples of paraffin-embedded tumour tissue from 43 children with unilateral retinoblastoma were collected to investigate the presence of HPV DNA using polymerase chain reaction (PCR) and dot blot hybridization. RESULTS: Oncogenic HPV DNA types 16 and 35 were detected in 12 (27.9%) of 43 tumour specimens. A higher frequency of differentiated tumours (63.3%) was observed among the HPV-positive tumours. CONCLUSIONS: Future studies are necessary to demonstrate an association between HPV and sporadic retinoblastoma.
Authors: Julia E Heck; Christina A Lombardi; Travis J Meyers; Myles Cockburn; Michelle Wilhelm; Beate Ritz Journal: Cancer Causes Control Date: 2012-07-29 Impact factor: 2.506
Authors: Beatriz de Camargo; Juliana Moreira de Oliveira Ferreira; Rejane de Souza Reis; Sima Ferman; Marceli de Oliveira Santos; Maria S Pombo-de-Oliveira Journal: BMC Cancer Date: 2011-05-05 Impact factor: 4.430
Authors: Julia E Heck; Negar Omidakhsh; Saeedeh Azary; Beate Ritz; Ondine S von Ehrenstein; Greta R Bunin; Arupa Ganguly Journal: BMC Cancer Date: 2015-10-19 Impact factor: 4.430