OBJECTIVE: To determine whether serum concentrations of 2 CXC chemokines, interleukin 8 (IL-8) and growth-regulated oncogene-alpha (GRO-alpha), which are potent chemoattractants and activators for neutrophils, are elevated and whether they correlate with clinical features in patients with systemic sclerosis (SSc). METHODS: Serum samples from patients with diffuse cutaneous SSc (dSSc; n = 36), limited cutaneous SSc (lSSc; n = 42), systemic lupus erythematosus (SLE; n = 15), dermatomyositis (DM; n = 15), and healthy controls (n = 35) were examined by ELISA. RESULTS: Serum IL-8 was detected significantly more frequently in patients with dSSc (61%) and lSSc (55%) relative to healthy controls (6%), patients with SLE (7%), and those with DM (13%). Similarly, serum GRO-alpha concentrations in SSc patients were significantly increased compared with controls, patients with SLE, or those with DM. Elevated IL-8 concentrations significantly correlated with decreased % DLCO and rheumatoid factor positivity, while increased GRO-alpha levels were significantly associated with decreased % DLCO and % vital capacity, involvement of kidney and muscle, the presence of anti-topoisomerase I antibody, and increased serum IgG levels. CONCLUSION: Our results suggest that the elevation of serum levels of the CXC chemokines IL-8 and GRO-alpha is specific to SSc and that the elevation of CXC chemokines, particularly GRO-alpha, correlates with the involvement of internal organs, especially pulmonary damage.
OBJECTIVE: To determine whether serum concentrations of 2 CXC chemokines, interleukin 8 (IL-8) and growth-regulated oncogene-alpha (GRO-alpha), which are potent chemoattractants and activators for neutrophils, are elevated and whether they correlate with clinical features in patients with systemic sclerosis (SSc). METHODS: Serum samples from patients with diffuse cutaneous SSc (dSSc; n = 36), limited cutaneous SSc (lSSc; n = 42), systemic lupus erythematosus (SLE; n = 15), dermatomyositis (DM; n = 15), and healthy controls (n = 35) were examined by ELISA. RESULTS: Serum IL-8 was detected significantly more frequently in patients with dSSc (61%) and lSSc (55%) relative to healthy controls (6%), patients with SLE (7%), and those with DM (13%). Similarly, serum GRO-alpha concentrations in SSc patients were significantly increased compared with controls, patients with SLE, or those with DM. Elevated IL-8 concentrations significantly correlated with decreased % DLCO and rheumatoid factor positivity, while increased GRO-alpha levels were significantly associated with decreased % DLCO and % vital capacity, involvement of kidney and muscle, the presence of anti-topoisomerase I antibody, and increased serum IgG levels. CONCLUSION: Our results suggest that the elevation of serum levels of the CXC chemokines IL-8 and GRO-alpha is specific to SSc and that the elevation of CXC chemokines, particularly GRO-alpha, correlates with the involvement of internal organs, especially pulmonary damage.
Authors: Eugeniusz Hrycek; Andrzej Franek; Edward Błaszczak; Justyna Dworak; Antoni Hrycek Journal: Rheumatol Int Date: 2012-03-30 Impact factor: 2.631
Authors: Pei-Suen Tsou; Bradley J Rabquer; Ray A Ohara; William A Stinson; Phillip L Campbell; M Asif Amin; Beatrix Balogh; George Zakhem; Paul A Renauer; Ann Lozier; Eshwar Arasu; G Kenneth Haines; Bashar Kahaleh; Elena Schiopu; Dinesh Khanna; Alisa E Koch Journal: Rheumatology (Oxford) Date: 2015-12-24 Impact factor: 7.580
Authors: Paola Coral-Alvarado; Gerardo Quintana; Maria Fernanda Garces; Libia Alexandra Cepeda; Jorge Eduardo Caminos; Federico Rondon; Antonio Iglesias-Gamarra; Jose Felix Restrepo Journal: Rheumatol Int Date: 2008-12-31 Impact factor: 2.631
Authors: Chiara Bellocchi; Jun Ying; Ellen A Goldmuntz; Lynette Keyes-Elstein; John Varga; Monique E Hinchcliff; Marka A Lyons; Peter McSweeney; Daniel E Furst; Richard Nash; Leslie J Crofford; Beverly Welch; Jonathan G Goldin; Ashley Pinckney; Maureen D Mayes; Keith M Sullivan; Shervin Assassi Journal: Arthritis Rheumatol Date: 2021-02-28 Impact factor: 10.995
Authors: Katrin Schmidt; Lorena Martinez-Gamboa; Susan Meier; Christian Witt; Christian Meisel; Leif G Hanitsch; Mike O Becker; Doerte Huscher; Gerd R Burmester; Gabriela Riemekasten Journal: Arthritis Res Ther Date: 2009-07-17 Impact factor: 5.156