Literature DB >> 12857931

E4orf3 is necessary for enhanced S-phase replication of cell cycle-restricted subgroup C adenoviruses.

Robin N Shepard1, David A Ornelles.   

Abstract

E1B-55K-mutant or E4orf6-mutant adenoviruses replicate more effectively after infecting cells in S phase than after infecting cells in G(1). Enhanced S-phase replication of the E4orf6-mutant viruses requires the E4orf3 gene. This report demonstrates that the E4orf3 gene is also required for enhanced S-phase replication of the E1B-55K-mutant virus.

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Year:  2003        PMID： 12857931      PMCID： PMC165245          DOI： 10.1128/jvi.77.15.8593-8595.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  14 in total

1.  Roles for the E4 orf6, orf3, and E1B 55-kilodalton proteins in cell cycle-independent adenovirus replication.

Authors:  F D Goodrum; D A Ornelles
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

2.  Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection.

Authors:  D D Barker; A J Berk
Journal:  Virology       Date:  1987-01       Impact factor: 3.616

3.  Response of individual adenovirus promoters to the products of the E1A gene.

Authors:  C V Dery; C H Herrmann; M B Mathews
Journal:  Oncogene       Date:  1987       Impact factor: 9.867

Review 4.  Oncolytic virotherapy for cancer with the adenovirus dl1520 (Onyx-015): results of phase I and II trials.

Authors:  D Kirn
Journal:  Expert Opin Biol Ther       Date:  2001-05       Impact factor: 4.388

5.  Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff.

Authors:  D N Halbert; J R Cutt; T Shenk
Journal:  J Virol       Date:  1985-10       Impact factor: 5.103

6.  The E4-6/7 protein functionally compensates for the loss of E1A expression in adenovirus infection.

Authors:  R J O'Connor; P Hearing
Journal:  J Virol       Date:  2000-07       Impact factor: 5.103

7.  Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.

Authors:  Travis H Stracker; Christian T Carson; Matthew D Weitzman
Journal:  Nature       Date:  2002-07-18       Impact factor: 49.962

8.  Prevalence and quantitation of species C adenovirus DNA in human mucosal lymphocytes.

Authors:  C T Garnett; D Erdman; W Xu; Linda R Gooding
Journal:  J Virol       Date:  2002-11       Impact factor: 5.103

9.  Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells.

Authors:  N Jones; T Shenk
Journal:  Cell       Date:  1979-07       Impact factor: 41.582

10.  The adenovirus e3 promoter is sensitive to activation signals in human T cells.

Authors:  Jeffrey A Mahr; Jeremy M Boss; Linda R Gooding
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103
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  17 in total

1.  Diverse roles for E4orf3 at late times of infection revealed in an E1B 55-kilodalton protein mutant background.

Authors:  Robin N Shepard; David A Ornelles
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

2.  The adenovirus E4 ORF3 protein binds and reorganizes the TRIM family member transcriptional intermediary factor 1 alpha.

Authors:  Mark A Yondola; Patrick Hearing
Journal:  J Virol       Date:  2007-02-07       Impact factor: 5.103

3.  Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection.

Authors:  Kasey A Karen; Patrick Hearing
Journal:  J Virol       Date:  2011-02-23       Impact factor: 5.103

4.  Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.

Authors:  Sook-Young Sohn; Patrick Hearing
Journal:  J Virol       Date:  2012-06-27       Impact factor: 5.103

5.  Identifying Host Factors Associated with DNA Replicated During Virus Infection.

Authors:  Emigdio D Reyes; Katarzyna Kulej; Neha J Pancholi; Lisa N Akhtar; Daphne C Avgousti; Eui Tae Kim; Daniel K Bricker; Lynn A Spruce; Sarah A Koniski; Steven H Seeholzer; Stuart N Isaacs; Benjamin A Garcia; Matthew D Weitzman
Journal:  Mol Cell Proteomics       Date:  2017-10-02       Impact factor: 5.911

6.  Adenovirus replaces mitotic checkpoint controls.

Authors:  Roberta L Turner; Peter Groitl; Thomas Dobner; David A Ornelles
Journal:  J Virol       Date:  2015-02-18       Impact factor: 5.103

7.  Adenovirus E4 ORF3 protein inhibits the interferon-mediated antiviral response.

Authors:  Amanda J Ullman; Nancy C Reich; Patrick Hearing
Journal:  J Virol       Date:  2007-02-14       Impact factor: 5.103

8.  A dynamical systems model for combinatorial cancer therapy enhances oncolytic adenovirus efficacy by MEK-inhibition.

Authors:  Neda Bagheri; Marisa Shiina; Douglas A Lauffenburger; W Michael Korn
Journal:  PLoS Comput Biol       Date:  2011-02-17       Impact factor: 4.475

9.  Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein.

Authors:  Amanda J Ullman; Patrick Hearing
Journal:  J Virol       Date:  2008-05-14       Impact factor: 5.103

10.  E4orf1 limits the oncolytic potential of the E1B-55K deletion mutant adenovirus.

Authors:  Michael A Thomas; Robin S Broughton; Felicia D Goodrum; David A Ornelles
Journal:  J Virol       Date:  2009-01-07       Impact factor: 5.103
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