Literature DB >> 12857930

The gammaherpesvirus chemokine binding protein binds to the N terminus of CXCL8.

Louise M C Webb1, Ian Clark-Lewis, Antonio Alcami.   

Abstract

Viruses encode proteins that disrupt chemokine responses. The murine gammaherpesvirus 68 gene M3 encodes a chemokine binding protein (vCKBP-3) which has no sequence similarity to chemokine receptors but inhibits chemokine receptor binding and activity. We have used a panel of CXCL8 analogs to identify the structural requirements for CXCL8 to bind to vCKBP-3 in a scintillation proximity assay. Our data suggest that vCKBP-3 acts by mimicking the binding of chemokine receptors to CXCL8.

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Year:  2003        PMID： 12857930      PMCID： PMC165246          DOI： 10.1128/jvi.77.15.8588-8592.2003

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  24 in total

Review 1.  Viral exploitation and subversion of the immune system through chemokine mimicry.

Authors:  P M Murphy
Journal:  Nat Immunol       Date:  2001-02       Impact factor: 25.606

2.  Critical role for a high-affinity chemokine-binding protein in gamma-herpesvirus-induced lethal meningitis.

Authors:  Victor van Berkel; Beth Levine; Sharookh B Kapadia; James E Goldman; Samuel H Speck; Herbert W Virgin
Journal:  J Clin Invest       Date:  2002-04       Impact factor: 14.808

3.  Structural basis of chemokine sequestration by a herpesvirus decoy receptor.

Authors:  Jennifer M Alexander; Christopher A Nelson; Victor van Berkel; Elaine K Lau; Joey M Studts; Tom J Brett; Samuel H Speck; Tracy M Handel; Herbert W Virgin; Daved H Fremont
Journal:  Cell       Date:  2002-11-01       Impact factor: 41.582

Review 4.  Chemokines and leukocyte traffic.

Authors:  M Baggiolini
Journal:  Nature       Date:  1998-04-09       Impact factor: 49.962

5.  Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor.

Authors:  B T Seet; R Singh; C Paavola; E K Lau; T M Handel; G McFadden
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-24       Impact factor: 11.205

6.  The viral CC chemokine-binding protein vCCI inhibits monocyte chemoattractant protein-1 activity by masking its CCR2B-binding site.

Authors:  C G Beck; C Studer; J F Zuber; B J Demange; U Manning; R Urfer
Journal:  J Biol Chem       Date:  2001-09-10       Impact factor: 5.157

7.  Identification of a gammaherpesvirus selective chemokine binding protein that inhibits chemokine action.

Authors:  V van Berkel; J Barrett; H L Tiffany; D H Fremont; P M Murphy; G McFadden; S H Speck; I V Virgin HW
Journal:  J Virol       Date:  2000-08       Impact factor: 5.103

8.  Identification of a glycosaminoglycan binding surface on human interleukin-8.

Authors:  G S Kuschert; A J Hoogewerf; A E Proudfoot; C W Chung; R M Cooke; R E Hubbard; T N Wells; P N Sanderson
Journal:  Biochemistry       Date:  1998-08-11       Impact factor: 3.162

9.  A secreted chemokine binding protein encoded by murine gammaherpesvirus-68 is necessary for the establishment of a normal latent load.

Authors:  A Bridgeman; P G Stevenson; J P Simas; S Efstathiou
Journal:  J Exp Med       Date:  2001-08-06       Impact factor: 14.307

Review 10.  Viral mimicry of cytokines, chemokines and their receptors.

Authors:  Antonio Alcami
Journal:  Nat Rev Immunol       Date:  2003-01       Impact factor: 53.106
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  4 in total

1.  Human cytomegalovirus immediate-early 2 protein IE86 blocks virus-induced chemokine expression.

Authors:  R Travis Taylor; Wade A Bresnahan
Journal:  J Virol       Date:  2006-01       Impact factor: 5.103

2.  Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.

Authors:  Limin Shang; Nanthakumar Thirunarayanan; Abel Viejo-Borbolla; Andrea P Martin; Milena Bogunovic; Federica Marchesi; Jay C Unkeless; Yin Ho; Glaucia C Furtado; Antonio Alcami; Miriam Merad; Lloyd Mayer; Sergio A Lira
Journal:  Gastroenterology       Date:  2009-06-06       Impact factor: 22.682

3.  Inhibition of intimal hyperplasia in transgenic mice conditionally expressing the chemokine-binding protein M3.

Authors:  Robert Pyo; Kristian K Jensen; Maria T Wiekowski; Denise Manfra; Antonio Alcami; Mark B Taubman; Sergio A Lira
Journal:  Am J Pathol       Date:  2004-06       Impact factor: 4.307

Review 4.  Regulation of Chemokine Function: The Roles of GAG-Binding and Post-Translational Nitration.

Authors:  Sarah Thompson; Beatriz Martínez-Burgo; Krishna Mohan Sepuru; Krishna Rajarathnam; John A Kirby; Neil S Sheerin; Simi Ali
Journal:  Int J Mol Sci       Date:  2017-08-03       Impact factor: 5.923
  4 in total

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