Literature DB >> 12855049

Effects of chronic hypoxia on maternal vasodilation and vascular reactivity in guinea pig and ovine pregnancy.

Margueritte M White1, Lubo Zhang.   

Abstract

During pregnancy, exposure to chronic hypoxia is thought to be associated with an increased risk of preeclampsia and fetal intrauterine growth restriction (IUGR). While some studies suggest that this process may be mediated through effects of chronic hypoxia on uterine artery vasodilation and growth, these observations are likely to be species specific and may represent genetic variability in maternal adaptation to hypoxia. This review is a comparative analysis of the effects of chronic hypoxia on vascular reactivity in pregnant and nonpregnant guinea pig and sheep. Data suggest that exposure to chronic hypoxia is associated with enhanced uterine artery blood flow in the sheep, whereas, in the guinea pig, blood flow is decreased.

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Year:  2003        PMID： 12855049     DOI： 10.1089/152702903322022776

Source DB:  PubMed          Journal:  High Alt Med Biol        ISSN： 1527-0297            Impact factor:   1.981


  15 in total

1.  Chronic hypoxia suppresses pregnancy-induced upregulation of large-conductance Ca2+-activated K+ channel activity in uterine arteries.

Authors:  Xiang-Qun Hu; Daliao Xiao; Ronghui Zhu; Xiaohui Huang; Shumei Yang; Sean M Wilson; Lubo Zhang
Journal:  Hypertension       Date:  2012-06-04       Impact factor: 10.190

Review 2.  Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals?

Authors:  James A Armitage; Imran Y Khan; Paul D Taylor; Peter W Nathanielsz; Lucilla Poston
Journal:  J Physiol       Date:  2004-09-30       Impact factor: 5.182

3.  Chronic hypoxia during gestation causes epigenetic repression of the estrogen receptor-α gene in ovine uterine arteries via heightened promoter methylation.

Authors:  Chiranjib Dasgupta; Man Chen; Haitao Zhang; Shumei Yang; Lubo Zhang
Journal:  Hypertension       Date:  2012-07-09       Impact factor: 10.190

4.  PKC regulates alpha(1)-adrenoceptor-mediated contractions and baseline Ca(2+) sensitivity in the uterine arteries of nonpregnant and pregnant sheep acclimatized to high altitude hypoxia.

Authors:  Daliao Xiao; Xiaohui Huang; Lawrence D Longo; Lubo Zhang
Journal:  High Alt Med Biol       Date:  2010       Impact factor: 1.981

5.  Feto- and utero-placental vascular adaptations to chronic maternal hypoxia in the mouse.

Authors:  Lindsay S Cahill; Monique Y Rennie; Johnathan Hoggarth; Lisa X Yu; Anum Rahman; John C Kingdom; Mike Seed; Christopher K Macgowan; John G Sled
Journal:  J Physiol       Date:  2017-09-24       Impact factor: 5.182

6.  Chronic hypoxia inhibits pregnancy-induced upregulation of SKCa channel expression and function in uterine arteries.

Authors:  Ronghui Zhu; Xiang-Qun Hu; Daliao Xiao; Shumei Yang; Sean M Wilson; Lawrence D Longo; Lubo Zhang
Journal:  Hypertension       Date:  2013-05-28       Impact factor: 10.190

7.  Lower uterine artery blood flow and higher endothelin relative to nitric oxide metabolite levels are associated with reductions in birth weight at high altitude.

Authors:  Colleen Glyde Julian; Henry L Galan; Megan J Wilson; Wendy Desilva; Darleen Cioffi-Ragan; Joel Schwartz; Lorna G Moore
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-06-25       Impact factor: 3.619

8.  Chronic hypoxia increases pressure-dependent myogenic tone of the uterine artery in pregnant sheep: role of ERK/PKC pathway.

Authors:  Katherine Chang; Daliao Xiao; Xiaohui Huang; Lawrence D Longo; Lubo Zhang
Journal:  Am J Physiol Heart Circ Physiol       Date:  2009-04-17       Impact factor: 4.733

9.  Gestational hypoxia induces preeclampsia-like symptoms via heightened endothelin-1 signaling in pregnant rats.

Authors:  Jianjun Zhou; Daliao Xiao; Yali Hu; Zhiqun Wang; Alexandra Paradis; Eugenia Mata-Greenwood; Lubo Zhang
Journal:  Hypertension       Date:  2013-07-01       Impact factor: 10.190

10.  Early fetal hypoxia leads to growth restriction and myocardial thinning.

Authors:  Margie Ream; Alisa M Ray; Rashmi Chandra; Dona M Chikaraishi
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-05-28       Impact factor: 3.619
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