Dennis M Robertson1. 1. Department of Ophthalmology, Mayo Clinic, Rochester, MN 55905, USA. robertson/dennis@mayo.edu
Abstract
PURPOSE: To describe the use of transpupillary thermotherapy in the management of two small choroidal melanomas that continued to grow following Iodine-125 brachytherapy. METHODS: Case reports from a tertiary care center. RESULTS: One small growing choroidal melanoma showed a partial response to Iodine-125 brachytherapy; four years later, it regrew to a thickness of 2.7 mm. After transpupillary thermotherapy (TTT), the tumor regressed to a flat scar and has remained inactive for more than three years. A second small melanoma failed to show regression after Iodine-125 brachytherapy; it progressively grew to 3.6 mm. TTT was used to treat the tumor on two successive occasions six weeks apart. The tumor regressed to a flat scar within three months and has remained inactive for 2.5 years. CONCLUSION: TTT may be considered as a rescue treatment for small choroidal melanomas that have failed to respond satisfactorily to brachytherapy.
PURPOSE: To describe the use of transpupillary thermotherapy in the management of two small choroidal melanomas that continued to grow following Iodine-125 brachytherapy. METHODS: Case reports from a tertiary care center. RESULTS: One small growing choroidal melanoma showed a partial response to Iodine-125 brachytherapy; four years later, it regrew to a thickness of 2.7 mm. After transpupillary thermotherapy (TTT), the tumor regressed to a flat scar and has remained inactive for more than three years. A second small melanoma failed to show regression after Iodine-125 brachytherapy; it progressively grew to 3.6 mm. TTT was used to treat the tumor on two successive occasions six weeks apart. The tumor regressed to a flat scar within three months and has remained inactive for 2.5 years. CONCLUSION: TTT may be considered as a rescue treatment for small choroidal melanomas that have failed to respond satisfactorily to brachytherapy.
Authors: E Weis; T G Salopek; J G McKinnon; M P Larocque; C Temple-Oberle; T Cheng; J McWhae; R Sloboda; M Shea-Budgell Journal: Curr Oncol Date: 2016-02-18 Impact factor: 3.677